Amiloride hydrochloride

Cat. No. 0890

Amiloride hydrochloride C6H8ClN7O.HCl [2016-88-8]

Price and Availability

For Amiloride hydrochloride pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 3,5-Diamino-N-(aminoiminomethyl)-6-chloropyrazinecarboxamide hydrochloride

Biological Activity

Na+ channel blocker. Defines the I2A-amiloride sensitive and I2B-amiloride insensitive imidazoline binding Blocks TRPP3, acid sensing- (ASIC) and mechanogated membrane-ion channels, as well as the Na+/H+ exchanger. Also inhibits urokinase-type plasminogen activator (uPA); has no effect on tissue-type plasminogen activator.

Technical Data

Soluble to 10 mM in water with gentle warming
>98 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Jetti et al (2010) Evaluation of the role of nitric oxide in acid sensing ion channel mediated cell death. Nitric Oxide 22 213. PMID: 20045740.

Dai et al (2007) Inhibition of TRPP3 channel by amiloride and analogs. Mol.Pharmacol. 72 1576. PMID: 17804601.

Hamill and McBride (1996) The pharmacology of mechanogated membrane ion channels. Pharmacol.Rev. 48 231. PMID: 8804105.

Ernsberger et al (1992) A second generation of centrally acting antihypertensive agents act on putative I1-imidazoline receptors. J.Cardiovasc.Pharmacol. 20 S1.

Kleyman et al (1988) Amiloride and its analogues as tools in the study of ion transport. J.Membr.Biol. 105 1. PMID: 2852254.

Vassalli et al (1987) Amiloride selectively inhibits the urokinase-type plasminogen activator. 214 187. PMID: 3106085.

If you know of a relevant reference for Amiloride hydrochloride please let us know.

Citations are publications that use Tocris products. Selected citations for Amiloride hydrochloride include:

Korang-Yeboah et al (2015) Polycaprolactone/maltodextrin nanocarrier for intracellular drug delivery: formulation, uptake mechanism, internalization kinetics, and subcellular localization. J Neurosci 10 4763. PMID: 26251597.

Jeong et al (2013) Antinociceptive effects of amiloride and benzamil in neuropathic pain model rats. Int J Nanomedicine 28 1238. PMID: 23960454.

Do you know of a great paper that uses Amiloride hydrochloride from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Amiloride hydrochloride, supplier, I2, selective, ligands, differentiates, I2A, I2B, Na+, channel, blockers, Imidazoline, Receptors, Sodium, NaV, Channels, voltage-gated, voltage-dependent, NHE, Na+, H+, exchanger, ASIC, upa, urokinase-type, plasminogen, inhibitors, inhibits, Tocris Bioscience, Voltage-gated Sodium (NaV) Channel Blocker products

Quick Order

Find multiple products by catalog number

divider line

Pain Research Product Guide

Pain Research Product Guide

Our Pain guide highlights over 280 products for Pain research. Request copy or view PDF today.

divider line

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

New Products in this Area


Potent and selective Nav1.6 channel blocker

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.