Orexin B (mouse)
Cat. No. 1457
Biological ActivityEndogenous agonist at orexin receptors. May be involved in the regulation of feeding, sleep-wake cycle and other hypothalamic functions.
(Modifications: Met-28 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kilduff and Peyron (2000) The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders. TiNS 23 359. PMID: 10906799.
Smart (1999) Orexins: a new family of neuropeptides. Br.J.Anaesth. 83 695. PMID: 10690128.
Sakurai et al (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour. Cell 92 573. PMID: 9491897.
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Citations are publications that use Tocris products. Selected citations for Orexin B (mouse) include:
Guo and Feng (2012) OX2R activation induces PKC-mediated ERK and CREB phosphorylation. Exp Cell Res 318 2004. PMID: 22652455.
Holland et al (2005) Orexin 1 receptor activation attenuates neurogenic dural vasodilation in an animal model of trigeminovascular nociception. J Biol Chem 315 1380. PMID: 16160082.
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Keywords: Orexin B (mouse), supplier, Endogenous, agonists, OX1, OX2, Orexin, Non-Selective, Receptors, OrexinB, (mouse), Tocris Bioscience, Non-selective Orexin Agonist products