PNU 37883 hydrochloride
Cat. No. 2095
Chemical Name: N-Cyclohexyl-N'-tricyclo[188.8.131.52,7]
Biological ActivityNovel antagonist selective for the vascular form of Kir6 (KATP) channel; inhibits Kir6 currents in isolated mesenteric artery smooth muscle cells (Kd = 65 nM) but not in cardiac or skeletal myocytes. Inhibits blood vessel relaxation and hypotension induced by pinacidil in vivo. Displays weak diuretic effects.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kovalev et al (2004) Molecular analysis of the subtype-selective inhibition of cloned KATP channels by PNU-37883A. Br.J.Pharmacol. 141 867. PMID: 14757705.
Cui et al (2003) Different molecular sites of action for the KATP channel inhibitors, PNU-99963 and PNU-37883A. Br.J.Pharmacol. 139 122. PMID: 12746230.
Humphrey and Ludens (1998) KATP-blocking diuretic PNU-37883A reduces plasma renin activity in dogs. J.Cardiovasc.Pharmacol. 31 894. PMID: 9641474.
If you know of a relevant reference for PNU 37883 hydrochloride please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses PNU 37883 hydrochloride from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: PNU 37883 hydrochloride, supplier, Vascular, KATP, channels, blockers, Potassium, KIR, Inward, Rectifier, K+, PNU37883, hydrochloride, antagonist, Kir6, Tocris Bioscience, Inward Rectifier Potassium (Kir) Channel Blocker products