Orexin B (human)

Cat. No. 1456

Orexin B (human) Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2

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Biological Activity

Endogenous agonist at orexin receptors (Ki values are 420 and 36 nM for OX1 and OX2 receptors, respectively). Stimulates feeding following central administration and may be involved in the control of sleep-wake cycle and other hypothalamic functions. Also neuroprotective for dopaminergic neurons in rat midbrain cultures.

Technical Data

M.Wt:
2899.36
Formula:
C123H212N44O35S
Sequence:
RSGPPGLQGRLQRLLQASGNHAAGILTM

(Modifications: Met-28 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
205640-91-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Guerreiro et al (2015) The sleep-modulating peptide orexin-B protects midbrain dopamine neurons from degeneration, alone or in cooperation with nicotine. Mol.Pharmacol. 87 525. PMID: 25552485.

Kilduff and Peyron (2000) The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders. TiNS 23 359. PMID: 10906799.

Smart (1999) Orexins: a new family of neuropeptides. Br.J.Anaesth. 83 695. PMID: 10690128.

Sakurai et al (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour. Cell 92 573. PMID: 9491897.

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Citations are publications that use Tocris products. Selected citations for Orexin B (human) include:

Guerreiro et al (2015) The sleep-modulating peptide orexin-B protects midbrain dopamine neurons from degeneration, alone or in cooperation with nicotine. Mol.Pharmacol. 87 525. PMID: 25552485 .

Malherbe et al (2009) Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX(2) receptor. Br.J.Pharmacol. 156 1326. PMID: 19751316.

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Keywords: Orexin B (human), supplier, Endogenous, agonists, OX1, OX2, Orexin, Non-Selective, Receptors, OrexinB, (human), Tocris Bioscience, Non-selective Orexin Agonist products

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