Methyllycaconitine citrate

Cat. No. 1029

Methyllycaconitine citrate C37H50N2O10.C6H8O7 [112825-05-5]

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Alternative Name: MLA

Chemical Name: [1α,4(S),6β,14α,16β]-20-Ethyl-1,6,14,16-tetramethoxy-4-[[[2-(3-methyl-2,5-dioxo-1-pyrrolidinyl)benzoyl]oxy]methyl]aconitane-7,8-diol citrate

Biological Activity

Potent antagonist for α7-containing neuronal nicotinic receptors (Ki = 1.4 nM). Interacts with α4β2 and α6β2 receptors at concentrations > 40 nM. Attenuates METH-induced neurotoxicity in mouse striatum in vivo.

Technical Data

M.Wt:
874.93
Formula:
C37H50N2O10.C6H8O7
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Storage:
Desiccate at -20°C
CAS No:
112825-05-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Escubedo et al (2005) Methyllycaconitine prevents methamphetamine-induced effects in mouse striatum: involvement of α7 nicotinic receptors. J.Pharmacol.Exp.Ther. 315 658. PMID: 16076935.

Dobelis et al (1999) Effects of delphinium alkaloids on neuromuscular transmission. J.Pharmacol.Exp.Ther. 291 538. PMID: 10525069.

Ward et al (1990) Methyllycaconitine: a selective probe for neuronal a-bungarotoxin binding sites. FEBS Lett. 270 45. PMID: 2226787.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Methyllycaconitine citrate include:

Kiss et al (2014) Nicotinic acetylcholine receptors containing the α7-like subunit mediate contractions of muscles responsible for space positioning of the snail, Helix pomatia L. tentacle. PLoS One 9 e109538. PMID: 25303328.

Brown et al (2013) Nicotine induces the up-regulation of the α7-nicotinic receptor (α7-nAChR) in human squamous cell lung cancer cells via the Sp1/GATA protein pathway. J Biol Chem 288 33049. PMID: 24089524.

Callahan et al (2013) Positive allosteric modulator of α7 nicotinic-acetylcholine receptors, PNU-120596 augments the effects of donepezil on learning and memory in aged rodents and non-human primates. Neuropharmacology 67 201. PMID: 23168113.

Grimster et al (2012) Generation of candidate ligands for nicotinic acetylcholine receptors via in situ click chemistry with a soluble acetylcholine binding protein template. J Am Chem Soc 134 6732. PMID: 22394239.

Leão et al (2012) OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons. Nat Neurosci 15 1524. PMID: 23042082.

Collins and Millar (2010) Nicotinic acetylcholine receptor transmembrane mutations convert ivermectin from a positive to a negative allosteric modulator. Mol Pharmacol 78 198. PMID: 20463059.

Li et al (2010) Cytisine induces autonomic cardiovascular responses via activations of different nicotinic receptors. Auton Neurosci 154 14. PMID: 19887306.

Li et al (2009) Specific subtypes of nicotinic cholinergic receptors involved in sympathetic and parasympathetic cardiovascular responses. Neurosci Lett 462 20. PMID: 19573576.

Hansen et al (2005) Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations. EMBO J 24 3635. PMID: 16193063.

Do you know of a great paper that uses Methyllycaconitine citrate from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Methyllycaconitine citrate, supplier, α7, alpha7, a7, neuronal, nicotinic, receptors, antagonists, Nicotinic, Acetylcholine, nAChR, Tocris Bioscience, Nicotinic (α7) Receptor Antagonist products

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