Ambenonium dichloride

Cat. No. 0388

Ambenonium dichloride C28H42Cl4N4O2 [115-79-7]

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Chemical Name: N,N'-[(1,2-Dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl)]bis(2-chloro-N,N-diethylbenzenemethaminium) dichloride

Biological Activity

Extremely potent, selective and rapidly reversible inhibitor of acetylcholinesterase (AChE) (IC50 values are 0.000698 and 8.20 μM at AChE and BChE respectively).

Technical Data

Soluble to 100 mM in water
>99 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Bolognesi et al (2003) Design, synthesis and biological evaluation of ambenonium derivatives as AChE inhibitors. Farmaco 58 917. PMID: 13679187.

Hodge et al (1992) Ambenonium is a rapidly reversible noncovalent inhibitor of acetylcholinesterase, with one of the highest known affinities. Mol.Pharmacol. 41 937. PMID: 1588924.

Web (1965) Affinity for benzoquinonium, and ambenonium derivatives for the acetylcholine receptor, tested on the electroplax, and for acetylcholinesterase in solution. Biochim.Biophys.Acta. 102 172. PMID: 5833399.

Lands et al (1958) An investigation of the structure-activity correlations within a series of ambenonium analogs. J.Pharmacol.Exp.Ther. 123 121. PMID: 13550066.

If you know of a relevant reference for Ambenonium dichloride please let us know.

Citations are publications that use Tocris products. Selected citations for Ambenonium dichloride include:

Mamaligas et al (2016) Nicotinic and opioid receptor regulation of striatal dopamine D2-receptor mediated transmission Scientific Reports 6 37834. PMID: 27886263.

Shin et al (2015) Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens. Int J Mol Sci 112 8124. PMID: 26080439.

Do you know of a great paper that uses Ambenonium dichloride from Tocris? If so please let us know.

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Keywords: Ambenonium dichloride, supplier, Cholinesterase, inhibitors, inhibits, AChE, Acetylcholinesterase, Esterases, Acetylcholine, Tocris Bioscience, Cholinesterase Inhibitor products

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