Cat. No. 0388
Chemical Name: N,N'-[(1,2-Dioxo-1,2-ethanediyl)bis(
Biological ActivityExtremely potent, selective and rapidly reversible inhibitor of acetylcholinesterase (AChE) (IC50 values are 0.000698 and 8.20 μM at AChE and BChE respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Bolognesi et al (2003) Design, synthesis and biological evaluation of ambenonium derivatives as AChE inhibitors. Farmaco 58 917. PMID: 13679187.
Hodge et al (1992) Ambenonium is a rapidly reversible noncovalent inhibitor of acetylcholinesterase, with one of the highest known affinities. Mol.Pharmacol. 41 937. PMID: 1588924.
Web (1965) Affinity for benzoquinonium, and ambenonium derivatives for the acetylcholine receptor, tested on the electroplax, and for acetylcholinesterase in solution. Biochim.Biophys.Acta. 102 172. PMID: 5833399.
Lands et al (1958) An investigation of the structure-activity correlations within a series of ambenonium analogs. J.Pharmacol.Exp.Ther. 123 121. PMID: 13550066.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Ambenonium dichloride from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: Ambenonium dichloride, supplier, Cholinesterase, inhibitors, inhibits, AChE, Acetylcholinesterase, Esterases, Acetylcholine, Tocris Bioscience, Cholinesterase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Selective endothelial lipase inhibitor; orally bioavailable
September 14, 2016