(R)-(+)-8-Hydroxy-DPAT hydrobromide

Cat. No. 1080

(R)-(+)-8-Hydroxy-DPAT hydrobromide C16H25NO.HBr [78095-19-9]

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Chemical Name: (2R)-(+)-8-Hydroxy-2-(di-n-propylamino)tetralin hydrobromide

Biological Activity

Full 5-HT1A serotonin receptor agonist; more active enantiomer. Reduces hippocampal 5-HT levels following systemic administration in rats in vivo. More active enantiomer of 8-Hydroxy-DPAT hydrobromide (Cat. No. 0529). 7-Hydroxy-DPAT hydrobromide (Cat. No. 0706) also available.

Technical Data

M.Wt:
328.29
Formula:
C16H25NO.HBr
Solubility:
Soluble to 75 mM in water and to 75 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
78095-19-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Yoshitake and Kehr (2004) Differential effects of (R)-, (R, S)- and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on hippocampal serotonin release and induction of hypothermia in awake rats. Life Sci. 74 2865. PMID: 15050424.

Corrfield et al (1991) Intrinsic activity of enantiomers of 8-hydroxy-2-(di-n-propylamino)tetralin and its analogues at 5-hydroxytryptamine1A receptors that are negatively coupled to adenylate cyclase. Mol.Pharmacol. 39 780. PMID: 1828859.

Bjork et al (1989) Resolved N,N-dialkylated 2-amino-8-hydroxytetralins: stereoselective interactions with 5-HT1A receptors in the brain. J.Med.Chem. 32 779. PMID: 2522991.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for (R)-(+)-8-Hydroxy-DPAT hydrobromide include:

Cassilly et al (2016) SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A. Psychopharmacology (Berl) 11 e0154932. PMID: 27183222.

Wierońska et al (2015) The antipsychotic-like effects in rodents of the positive allosteric modulator Lu AF21934 involve 5-HT1A receptor signaling: mechanistic studies. Oncoscience 232 259. PMID: 25012236.

Rossi et al (2008) Differential regulation of serotonin-1A receptor-stimulated [35S]GTP gamma S binding in the dorsal raphe nucleus by citalopram and escitalopram. Eur J Pharmacol 583 103. PMID: 18289523.

Do you know of a great paper that uses (R)-(+)-8-Hydroxy-DPAT hydrobromide from Tocris? If so please let us know.

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Keywords: (R)-(+)-8-Hydroxy-DPAT hydrobromide, supplier, Selective, 5-HT1A, agonists, active, enantiomer, Serotonin, Receptors, Tocris Bioscience, 5-HT1A Receptor Agonist products

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