Pirenzepine dihydrochloride

Cat. No. 1071

Pirenzepine dihydrochloride C19H21N5O2.2HCl [29868-97-1]

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Chemical Name: 5,11-Dihydro-11-[(4-methyl-1-piperazinyl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one dihydrochloride

Biological Activity

M1 muscarinic receptor selective antagonist. Inverse agonist activity reported.

Technical Data

M.Wt:
424.33
Formula:
C19H21N5O2.2HCl
Solubility:
Soluble to 100 mM in water
Purity:
>98 %
Storage:
Store at RT
CAS No:
29868-97-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Daeffler et al (1999) Inverse agonist activity of pirenzepine at M2 muscarinic acetylcholine receptors. Br.J.Pharmacol. 126 1246. PMID: 10205015.

Eglen et al (1996) Muscarinic receptor subtypes and smooth muscle function. Pharmacol.Rev. 48 531. PMID: 8981565.

Doods et al (1994) Pharmacological profile of selective muscarinic receptor antagonists on guinea-pig ileal smooth muscle. Eur.J.Pharmacol. 253 275. PMID: 8200421.

Hammer et al (1980) Pirenzepine distinguishes between different subclasses of muscarinic receptors. Nature 283 90. PMID: 7350532.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Pirenzepine dihydrochloride include:

Tozzi et al (2015) Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system. Front Cell Neurosci 9 192. PMID: 26074768.

Mans et al (2014) An acetylcholinesterase inhibitor, eserine, induces long-term depression at CA3-CA1 synapses in the hippocampus of adult rats. J Neurophysiol 112 2388. PMID: 25143547.

Pacini et al (2014) M2muscarinic receptors inhibit cell proliferation and migration in urothelial bladder cancer cells. Cancer Biol Ther 15 1489. PMID: 25482946.

Tozzi et al (2012) A2A adenosine receptor antagonism enhances synaptic and motor effects of cocaine via CB1 cannabinoid receptor activation. PLoS One 7 e38312. PMID: 22715379.

Buchanan et al (2010) Facilitation of long-term potentiation by muscarinic M(1) receptors is mediated by inhibition of SK channels. Neuron 68 948. PMID: 21145007.

Do you know of a great paper that uses Pirenzepine dihydrochloride from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Pirenzepine dihydrochloride, supplier, Selective, M1, muscarinic, antagonists, Receptors, Acetylcholine, ACh, Tocris Bioscience, M1 Receptor Antagonist products

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