Guanfacine hydrochloride

Cat. No. 1030

Guanfacine hydrochloride C9H9Cl2N3O.HCl [29110-48-3]

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Chemical Name: [(2,6-Dichlorophenyl)acetyl]guanidine hydrochloride

Biological Activity

Selective α2A-adrenoceptor agonist (Kd = 31 nM). Displays 60-fold selectivity over α2B-adrenoceptors. Also available as part of the α2-Adrenoceptor Tocriset™.

Technical Data

M.Wt:
282.56
Formula:
C9H9Cl2N3O.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
29110-48-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Intengan and Smyth (1997) Alpha-2a/d adrenoceptor subtype stimulation by guanfacine increases osmolar clearance. J.Pharmacol.Exp.Ther. 281 48. PMID: 9103479.

Uhlen and Wikberg (1991) Delineation of rat kidney α2A- and α2B-adrenoceptors with [3H]RX821002 radioligand binding: computer modelling reveals that guanfacine is an α2A -selective compound. Eur.J.Pharmacol. 202 235. PMID: 1666366.

Merck Index 12 4590.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Guanfacine hydrochloride include:

An et al (2014) Neuritin can normalize neural deficits of Alzheimer's disease. Cell Death Dis 5 e1523. PMID: 25393479.

Hamby et al (2012) Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors. Pharmacol Res Perspect 32 14489. PMID: 23077035.

Do you know of a great paper that uses Guanfacine hydrochloride from Tocris? If so please let us know.

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Keywords: Guanfacine hydrochloride, supplier, α2A-adrenoceptor, alpha2A-adrenoceptor, a2a-adrenoceptor, a2a-adrenergic, α2a-adrenergic, alpha2a-adrenergic, agonists, Receptors, Tocris Bioscience, Adrenergic α2 Receptor Agonist products

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