Alrestatin

Cat. No. 0485

Alrestatin C14H9NO4 [51411-04-2]

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Chemical Name: 1,3-Dioxo-1H-benz[d,e]isoquinoline-2(3H)-acetic acid

Biological Activity

Specific inhibitor of aldose reductase (IC50 = 148 μM). Attenuates glucose-induced angiotensin II production in rat vascular smooth muscle in vitro.

Technical Data

M.Wt:
255.23
Formula:
C14H9NO4
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store at RT
CAS No:
51411-04-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Lavrentyev et al (2007) Mechanism of high glucose-induced angiotensin II production in rat vascular smooth muscle cells. Circ.Res. 101 455. PMID: 17626897.

Barski et al (1996) The C-terminal loop of aldehyde reductase determines the substrate and inhibitor specificity. Biochemistry 35 14276. PMID: 8916913.

Ehrig et al (1994) Mechanism of aldose reductase inhibition: binding of NADP+/NADPH and alrestatin-like inhibitors. Biochemistry 33 7157. PMID: 8003482.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Alrestatin include:

Bresson et al (2012) The Prostaglandin F Synthase Activity of the Human Aldose Reductase AKR1B1 Brings New Lenses to Look at Pathologic Conditions. Front Pharmacol 3 98. PMID: 22654757.

Lavrentyev and Malik (2009) High glucose-induced Nox1-derived superoxides downregulate PKC-betaII, which subsequently decreases ACE2 expression and ANG(1-7) formation in rat VSMCs. Am J Physiol Heart Circ Physiol 296 H106. PMID: 18978194.

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Keywords: Alrestatin, supplier, Aldose, reductases, inhibitors, inhibits, Carbohydrate, Metabolism, Tocris Bioscience, Aldose Reductase Inhibitor products

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