Cat. No. 0485

Alrestatin C14H9NO4 [51411-04-2]

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Chemical Name: 1,3-Dioxo-1H-benz[d,e]isoquinoline-2(3H)-acetic acid

Biological Activity

Specific inhibitor of aldose reductase (IC50 = 148 μM). Attenuates glucose-induced angiotensin II production in rat vascular smooth muscle in vitro.

Technical Data

Soluble to 100 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Lavrentyev et al (2007) Mechanism of high glucose-induced angiotensin II production in rat vascular smooth muscle cells. Circ.Res. 101 455. PMID: 17626897.

Barski et al (1996) The C-terminal loop of aldehyde reductase determines the substrate and inhibitor specificity. Biochemistry 35 14276. PMID: 8916913.

Ehrig et al (1994) Mechanism of aldose reductase inhibition: binding of NADP+/NADPH and alrestatin-like inhibitors. Biochemistry 33 7157. PMID: 8003482.

If you know of a relevant reference for Alrestatin please let us know.

Citations are publications that use Tocris products. Selected citations for Alrestatin include:

Mochin et al (2015) Hyperglycemia and redox status regulate RUNX2 DNA-binding and an angiogenic phenotype in endothelial cells. PLoS One 97 55. PMID: 25283348.

Bresson et al (2012) The Prostaglandin F Synthase Activity of the Human Aldose Reductase AKR1B1 Brings New Lenses to Look at Pathologic Conditions. Front Pharmacol 3 98. PMID: 22654757.

Lavrentyev and Malik (2009) High glucose-induced Nox1-derived superoxides downregulate PKC-betaII, which subsequently decreases ACE2 expression and ANG(1-7) formation in rat VSMCs. Am J Physiol Heart Circ Physiol 296 H106. PMID: 18978194.

Do you know of a great paper that uses Alrestatin from Tocris? If so please let us know.

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Keywords: Alrestatin, supplier, Aldose, reductases, inhibitors, inhibits, Carbohydrate, Metabolism, Tocris Bioscience, Aldose Reductase Inhibitor products

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