3-AQC

Cat. No. 0666

3-AQC C16H17N5.C4H4O4 [201216-42-4]

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Chemical Name: 3-(4-Allylpiperazin-1-yl)-2-quinoxalinecarbonitrile maleate

Biological Activity

A competitive 5-HT3 antagonist, almost 100 times more potent than tropisetron, but with widely differing activity in various tissues.

Technical Data

M.Wt:
395.42
Formula:
C16H17N5.C4H4O4
Solubility:
Soluble to 100 mM in DMSO
Storage:
Desiccate at -20°C
CAS No:
201216-42-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Buznikov et al (2005) The pre-nervous serotonergic system of developing sea urchin embryos and larvae: pharmacologic and immunocytochemical evidence. Neurochem.Res. 30 825. PMID: 16187217.

Durk et al (2005) 5-Hydroxytryptamine modulates cytokine and chemokine production in LPS-primed human monocytes via stimulation of different 5-HTR subtypes. Int.Immunol. 17 599. PMID: 15802305.

Monge et al (1993) Novel antagonists of 5-HT3 receptors. Synthesis and biological evaluation of piperazinylquinoxaline derivatives. J.Med.Chem. 36 2745. PMID: 8410988.

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Keywords: 3-AQC, supplier, 5-HT3, antagonists, Serotonin, Receptors, Tocris Bioscience, 5-HT3 Receptor Antagonist products

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5-HT Review

Written by N. Barnes & J. Neumaler

5-HT Receptors Scientific Review

Our 5-HT review summarizes the serotonin receptor subtypes and highlights their importance in mediating various physiological & pharmacological processes. Request copy or view PDF today.

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