(+)-AJ 76 hydrochloride
Cat. No. 0678
Chemical Name: (1S,2R)-cis-5-Methoxy-1-methyl-2-(N
Biological ActivityDopamine receptor antagonist with preferential action at presynaptic receptors (pKi values are 6.95, 6.67, 6.37, 6.21 and 6.07 at hD3. hD4, hD2S, hD2L and rD2 receptors respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Millan et al (2004) The role of dopamine D3 compared with dopamine D2 receptors in the control of locomotor activity: a combined behavioural and neurochemical analysis with novel, selective antagonists in rats. Psychopharmacology 174 341. PMID: 14985929.
Waters et al (1994) Intracerebral infusion of (+)-AJ76 and (+)-UH232: effects on dopamine release and metabolism in vivo. Eur.J.Pharmacol. 251 181. PMID: 8149975.
Kullingsjo et al (1991) Effects of repeated administration of the preferential dopamine autoreceptor antagonist, (+)-AJ76, on locomotor activity and brain DA metabolism in the rat. Eur.J.Pharmacol. 205 241. PMID: 1817961.
Johansson et al (1987) Resolved cis and trans-2-amino-5-methoxy-1-methyltetralins: central dopamine receptor agonists and antagonists. J.Med.Chem. 30 602. PMID: 3560156.
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