Cat. No. 0671
Chemical Name: 6-Isopropoxy-9-xanthone-2-carboxyli
Biological ActivityAntagonist at prostaglandin EP1 (pA2 = 6.8) and EP2 (Ki = 350 nM) receptors. Also weakly inhibits DP receptors (pA2 = 4.45).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
van der Merwe et al (2009) Prostaglandin E2 derived from cyclooxygenases 1 and 2 mediates intestinal epithelial ion transport stimulated by the activation of protease-activated receptor 2. J.Pharmacol.Exp.Ther. 329 747. PMID: 19190238.
Kiriyama et al (1997) Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br.J.Pharmacol. 122 217. PMID: 9313928.
Keery and Lumley (1988) AH 6809, a prostaglandin DP-receptor blocking drug on human platelets. Br.J.Pharmacol. 94 745. PMID: 2460179.
Coleman et al (1985) AH6809, a prostanoid EP1-receptor blocking drug. Br.J.Pharmacol. 85 273P.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for AH 6809 include:
Chia et al (2011) Protection of protease-activated receptor 2 mediated vasodilatation against angiotensin II-induced vascular dysfunction in mice. BMC Pharmacol 11 10. PMID: 21955547.
Walsh and Kinsella (2000) Regulation of the human prostanoid TPalpha and TPbeta receptor isoforms mediated through activation of the EP(1) and IP receptors. Br J Pharmacol 131 601. PMID: 11015313.
Do you know of a great paper that uses AH 6809 from Tocris? If so please let us know.
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Keywords: AH 6809, supplier, EP1, EP2, receptor, antagonists, DP, Receptors, prostanoid, receptors, prostaglandins, prostacyclins, eicosanoids, AH6809, Tocris Bioscience, Prostanoid Receptor Antagonist products
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