Orexin A (human, rat, mouse)
Cat. No. 1455
Biological ActivityEndogenous agonist at orexin receptors (Ki values are 20 and 38 nM for OX1 and OX2 receptors respectively). Stimulates feeding following central administration and may be involved in the control of sleep-wake cycle and other hypothalamic functions.
(Modifications: X = Glp, Disulfide bridge between 6 - 12, 7 - 14, Leu-33 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Kilduff and Peyron (2000) The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders. TiNS 23 359. PMID: 10906799.
Smart (1999) Orexins: a new family of neuropeptides. Br.J.Anaesth. 83 695. PMID: 10690128.
Sakurai et al (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour. Cell 92 573. PMID: 9491897.
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Citations are publications that use Tocris products. Selected citations for Orexin A (human, rat, mouse) include:
Guo and Feng (2012) OX2R activation induces PKC-mediated ERK and CREB phosphorylation. Exp Cell Res 318 2004. PMID: 22652455.
Moorman and Aston-Jones (2010) Orexin/hypocretin modulates response of ventral tegmental dopamine neurons to prefrontal activation: diurnal influences. J Neurosci 30 15585. PMID: 21084614.
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Keywords: Orexin A (human, rat, mouse), supplier, Endogenous, agonists, OX1, OX2, Orexin, Non-Selective, Receptors, OrexinA, (human, rat, mouse), Tocris Bioscience, Non-selective Orexin Agonist products
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September 14, 2016