Orexin A (human, rat, mouse)

Cat. No. 1455

Orexin A (human, rat, mouse) Glp-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2 (Disulfide bridge: 6-12 and 7-14)

Price and Availability

For Orexin A (human, rat, mouse) pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Biological Activity

Endogenous agonist at orexin receptors (Ki values are 20 and 38 nM for OX1 and OX2 receptors respectively). Stimulates feeding following central administration and may be involved in the control of sleep-wake cycle and other hypothalamic functions.

Technical Data

M.Wt:
3561.12
Formula:
C152H243N47O44S4
Sequence:
XPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL

(Modifications: X = Glp, Disulfide bridge between 6 - 12, 7 - 14, Leu-33 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
205640-90-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
Select another batch:

Kilduff and Peyron (2000) The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders. TiNS 23 359. PMID: 10906799.

Smart (1999) Orexins: a new family of neuropeptides. Br.J.Anaesth. 83 695. PMID: 10690128.

Sakurai et al (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour. Cell 92 573. PMID: 9491897.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Orexin A (human, rat, mouse) include:

Kim et al (2015) Involvement of Heme Oxygenase-1 in Orexin-A-induced Angiogenesis in Vascular Endothelial Cells. Brain Res 19 327. PMID: 26170736.

Guo and Feng (2012) OX2R activation induces PKC-mediated ERK and CREB phosphorylation. Exp Cell Res 318 2004. PMID: 22652455.

Moorman and Aston-Jones (2010) Orexin/hypocretin modulates response of ventral tegmental dopamine neurons to prefrontal activation: diurnal influences. J Neurosci 30 15585. PMID: 21084614.

Gompf and Aston-Jones (2008) Role of orexin input in the diurnal rhythm of locus coeruleus impulse activity. J Pharmacol Exp Ther 1224 43. PMID: 18614159.

Holland et al (2005) Orexin 1 receptor activation attenuates neurogenic dural vasodilation in an animal model of trigeminovascular nociception. Korean J Physiol Pharmacol 315 1380. PMID: 16160082.

Do you know of a great paper that uses Orexin A (human, rat, mouse) from Tocris? If so please let us know.show all ▼show less ▲

View Related Products by Target

View Related Products by Product Action

Keywords: Orexin A (human, rat, mouse), supplier, Endogenous, agonists, OX1, OX2, Orexin, Non-Selective, Receptors, OrexinA, (human, rat, mouse), Tocris Bioscience, Non-selective Orexin Agonist products

Quick Order

Find multiple products by catalog number

divider line

Peptide Hormone Receptors Product Listing

Peptide Hormone Receptors Product Listing

Our Peptide Hormone Receptors Listing highlights over 200 products for peptide hormone receptors. Request copy or view PDF today.

divider line

GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs. Request copy or view PDF today.

divider line

Appetite Modulation

Written by S. Tucci et al

Peptides Involved in Appetite Modulation Scientific Review

Our Peptides Involved in Appetite Modulation review gives an overview of the peptides implicated in appetite regulation and energy homeostasis. View PDF today.

divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.