Venlafaxine hydrochloride

Cat. No. 2917

Venlafaxine hydrochloride C17H27NO2.HCl [99300-78-4]

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Alternative Name: Wy 45030

Chemical Name: 1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride

Biological Activity

Dual serotonin/noradrenalin re-uptake inhibitor that displays ~ 30-fold higher affinity for SERT than NET (Ki values are 82 and 2480 nM respectively). Antidepressant; increases swimming and climbing behavior in the forced-swim test in rats.

Technical Data

M.Wt:
313.86
Formula:
C17H27NO2.HCl
Solubility:
Soluble to 100 mM in water and to 50 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
99300-78-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Gould et al (2006) A comparison of the chronic treatment effects of venlafaxine and other antidepressants on serotonin and norepinephrine transporters. Biol.Psychiatry 59 408. PMID: 16140280.

Magalas et al (2005) The serotonin/noradrenaline reuptake inhibitor venlafaxine attenuates acquistion, but not maintenance, of intravenous self-administration of heroin in rats. Eur.J.Pharmacol. 528 103. PMID: 16325805.

Bymaster et al (2001) Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacol. 25 871.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Venlafaxine hydrochloride include:

Stuart et al (2015) Distinct Neuropsychological Mechanisms May Explain Delayed- Versus Rapid-Onset Antidepressant Efficacy. Proc Natl Acad Sci U S A 40 2165. PMID: 25740288.

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Keywords: Venlafaxine hydrochloride, supplier, Dual, serotonin/noradrenaline, reuptake, inhibitors, inhibits, NET, Adrenergic, Transporters, Monoamine, Neurotransmitter, SERT, 5-HT, 5-Hydroxytryptamine, Wy45030, Tocris Bioscience, 5-HT Transporter Inhibitor products

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