SU 4312

Cat. No. 1459

SU 4312 C17H16N2O [5812-07-7]

Price and Availability

For SU 4312 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Name: DMBI

Chemical Name: 3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one

Biological Activity

Potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 values are 0.8 and 19.4 μM respectively). Selective over EGFR and c-Src tyrosine kinases.

Technical Data

M.Wt:
264.33
Formula:
C17H16N2O
Solubility:
Soluble to 100 mM in DMSO
Storage:
Desiccate at -20°C
CAS No:
5812-07-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Kendall et al (1999) Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues. J.Biol.Chem. 274 6453. PMID: 10037737.

Sun et al (1998) Synthesis and biological evaluations of 3-substituted indol-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases. J.Med.Chem. 41 2588. PMID: 9651163.

Zaman et al (1998) Tyrosine kinase activity of purified recombinant cytoplasmic domain of platelet-derived growth factor β-receptor (β-PDGFR) and discovery of a novel inhibitor of receptor tyrosine kinases. Biochem.Pharmacol. 57 57. PMID: 9920285.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for SU 4312 include:

Cole et al (2010) Synthetic heparan sulfate oligosaccharides inhibit endothelial cell functions essential for angiogenesis. PLoS One 5 e11644. PMID: 20657775.

Do you know of a great paper that uses SU 4312 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: SU 4312, supplier, Potent, inhibitors, VEGFR, tyrosine, kinase, Vascular, Endothelial, Growth, Factor, Receptors, KDR, Flt, Receptor, Tyrosine, Kinases, RTKs, SU4312, Tocris Bioscience, VEGFR Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

divider line

Kinases Product Listing

Kinases Product Listing

Highlights over 400 products for kinase research. Request copy or view PDF today.

divider line

VEGF Pathway & Anti-Angiogenic Therapy

Written by N. Ferrara & Y. Crawford

Angiogenesis Life Science Poster

A summary of antiangiogenic therapies targeting the VEGF pathway and the mechanisms of therapy resistance. Request copy today.

divider line

VEGF Pathway

VEGF Signaling Pathway

VEGF signaling regulates vascular development (vasculogenesis) and the formation of new blood vessels (angiogenesis). View pathway or download PDF today.

divider line

New Products in this Area

CP 724714

Potent and selective ErbB2 inhibitor

Mitoglitazone

Insulin sensitizer; exhibits low binding affinity at PPARγ

PF 6274484

High affinity and potent covalent EGFR kinase inhibitor

Canertinib dihydrochloride

Potent EGFR kinase inhibitor

CHMFL-FLT3-122

Potent and selective FLT3 inhibitor

GW 2580

Selective cFMS kinase inhibitor; orally bioavailable

Sign-up for new product e-alerts
divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.