Cat. No. 2090
Alternative Name: Calcium-like peptide 1
Biological ActivityCell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca2+-binding site; produces CaM-dependent activation of phosphodiesterase. Also binds to cytoplasmic sites on other Ca2+ channels, including NMDA and HIV-1 gp120-activated channels, inhibiting Ca2+-mediated cytotoxicity and apoptosis (IC50 = 52 μM). Inhibits VLA-5-mediated adhesion of mast cells to fibronectin in vitro and attenuates inflammatory cell influx in guinea pig lung in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Ten Broeke et al (2003) Ca2+ sensors modulate asthmatic symptoms in an allergic model for asthma. Eur.J.Pharmacol. 476 151. PMID: 12969760.
Houtman et al (2001) Attenuation of very late antigen-5-mediated adhesion of bone marrow-derived mast cells to fibronectin by peptides with inverted hydropathy to EF-hands. J.Immunol. 166 861. PMID: 11145661.
Manion et al (2000) A new type of Ca2+ channel blocker that targets Ca2+ sensors and prevents Ca2+-mediated apoptosis. FASEB J. 14 1297. PMID: 10877822.
Villain et al (2000) De novo design of peptides targeted to the EF hands of calmodulin. J.Biol.Chem. 274 2676.
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Citations are publications that use Tocris products. Selected citations for CALP1 include:
Tzeng et al (2012) The Ca(v)3.1 T-type calcium channel is required for neointimal formation in response to vascular injury in mice. Cardiovasc Res 96 533. PMID: 22886848.
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Keywords: CALP1, supplier, Cell-permeable, calmodulin, agonists, inhibitors, inhibits, Ca2+-sensitive, ion, channels, Ca2+, Binding, Protein, modulators, Calcium, Signaling, Signalling, Calcium-like, peptide1, Tocris Bioscience, Calcium Binding Protein Modulator Agonist products
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November 12 - 16, 2016
San Diego, CA, USA