Cat. No. 0284
Chemical Name: (1S,3R)-1-Aminocyclopentane-1,3-dic
Biological ActivityActive isomer of (±)-trans-ACPD (Cat. No. 0187). Agonist at both group I and II mGlu receptors (EC50 values are 5, 15, 42 and 60 μM at mGluR2, mGluR5, mGluR1 and mGluR6 respectively). NPEC-caged-(1S,3R)-ACPD also available (Cat. No. 3331). (±)-trans-ACPD (Cat. No. 0187) and cis-ACPD (Cat. No. 0186) also available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Conti et al (2002) Synthesis and pharmacology of 3-hydroxy-Δ2-isoxazoline-cyclopentance analogues of glutamic acid. Farmaco 57 889. PMID: 12484537.
Mistry and Challis (1996) Differences in agonist and antagonist activities for two indicies of metabotropic glutamate receptor-stimulated phosphoinositide turnover. Br.J.Pharmacol. 117 1735. PMID: 8732284.
Knopfel et al (1995) Metabotropic glutamate receptors: novel targets for drug development. J.Med.Chem. 38 1417. PMID: 7738999.
If you know of a relevant reference for (1S,3R)-ACPD please let us know.
Citations are publications that use Tocris products. Selected citations for (1S,3R)-ACPD include:
Tang et al (2015) Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP. J Neurosci 35 3016. PMID: 25698739.
Andlauer et al (2014) Drep-2 is a novel synaptic protein important for learning and memory. J Neurosci 3. PMID: 25392983.
Yamada et al (2008) Long-range axonal calcium sweep induces axon retraction. Sci Adv 28 4613. PMID: 18448637.
Do you know of a great paper that uses (1S,3R)-ACPD from Tocris? If so please let us know.
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Keywords: (1S,3R)-ACPD, supplier, Group, II, group, I, mGlur, agonists, Receptors, mGlu2, mGlu3, mGluR2, mGluR3, Glutamate, Metabotropic, mGlu1, mGlu5, mGluR1, mGluR5, Tocris Bioscience, Glutamate (Metabotropic) Group I Receptor Agonist products