(±)-trans-ACPD

Cat. No. 0187

trans-ACPD C7H11NO4 [67684-64-4]

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Chemical Name: (±)-1-Aminocyclopentane-trans-1,3-dicarboxylic acid

Biological Activity

Equimolecular mixture of (1S,3R)- and (1R,3S)-ACPD. Selective agonist for metabotropic glutamate receptors; active at both group I and group II mGlu receptors (EC50 values are 2, 15, 23 and ~800 μM at mGluR2, mGluR1, mGluR5 and mGluR4 respectively). (1S,3R)-ACPD (Cat. No. 0284) and cis-ACPD (Cat. No. 0186) also available.

Technical Data

M.Wt:
173.17
Formula:
C7H11NO4
Solubility:
Soluble to 5 mM in water with gentle warming and to 50 mM in 1eq. NaOH
Purity:
>99 %
Storage:
Store at RT
CAS No:
67684-64-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Conti et al (2002) Synthesis and pharmacology of 3-hydroxy-Δ2-isoxazoline-cyclopentance analogues of glutamic acid Farmaco 57 889. PMID: 12484537.

Knopfel et al (1995) Metabotropic glutamate receptors: novel targets for drug development. J.Med.Chem. 38 1417. PMID: 7738999.

Pin and Duvoisin (1995) The metabotropic glutamate receptors: structure and functions. Neuropharmacology 34 1. PMID: 7623957.

Nakanishi (1992) Molecular diversity of glutamate receptors and implications for brain functions. Science 258 597. PMID: 1329206.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for (±)-trans-ACPD include:

Coulon et al (2011) Activity Modes in Thalamocortical Relay Neurons are Modulated by G(q)/G(11) Family G-proteins - Serotonergic and Glutamatergic Signaling. Front Cell Neurosci 4 132. PMID: 21267426.

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Keywords: trans-ACPD, supplier, Group, II, group, I, mGlur, agonists, Receptors, mGlu2, mGlu3, mGluR2, mGluR3, Glutamate, Metabotropic, mGlu1, mGlu5, mGluR1, mGluR5, tacpd, trans-acpd, Tocris Bioscience, Glutamate (Metabotropic) Group I Receptor Agonist products

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