Galnon

Cat. No. 2085

Galnon Fmoc-β-cyclohexyl-Ala-Lys-(4-methyl-2-oxo-2H-1-benzopyran)

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Chemical Name: 3-Cyclohexyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-lysinamide

Biological Activity

Novel non-peptide galanin GAL1 and GAL2 receptor agonist (Ki values are 11.7 and 34.1 μM respectively). Stimulates insulin release in isolated pancreatic islets from normal and diabetic rats. Systemically active in vivo; displays anticonvulsant activity following i.p. administration in mice. Central and peripheral administration also transiently inhibits food intake in rats and mice.

Technical Data

M.Wt:
678.83
Formula:
C40H46N4O6
Sequence:
AK

(Modifications: Ala-1 = Fmoc-β-cyclohexyl-Ala, Lys-2 = Lys-(4-methyl-2-oxo-2H-1-benzopyran)

Solubility:
Soluble to 67.88 mg/ml in DMSO and to 16.97 mg/ml in ethanol with gentle warming
Storage:
Desiccate at -20°C
CAS No:
475115-35-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Lu et al (2005) A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus. Proc.Natl.Acad.Sci. 102 874. PMID: 15647369.

Quynh et al (2005) Effects of galnon, a non-peptide galanin-receptor agonist, on insulin release from rat pancreatic islets. Biochem.Biophys.Res.Comm. 328 213. PMID: 15670772.

Abramov et al (2004) Regulation of feeding by galnon. Neuropeptides 38 55. PMID: 15003717.

Saar et al (2002) Anticonvulsant activity of a nonpeptide galanin receptor agonist Proc.Natl.Acad.Sci.USA 99 7136. PMID: 12011470.

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Keywords: Galnon, supplier, Selective, non-peptide, GAL1, GalR1, agonists, Receptors, Galanin, Tocris Bioscience, Galanin Receptor Agonist products

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