Cat. No. 2085
Chemical Name: 3-Cyclohexyl-N-[(9H-fluoren-9-ylmet
Biological ActivityNovel non-peptide galanin GAL1 and GAL2 receptor agonist (Ki values are 11.7 and 34.1 μM respectively). Stimulates insulin release in isolated pancreatic islets from normal and diabetic rats. Systemically active in vivo; displays anticonvulsant activity following i.p. administration in mice. Central and peripheral administration also transiently inhibits food intake in rats and mice.
(Modifications: Ala-1 = Fmoc-β-cyclohexyl-Ala, Lys-2 = Lys-(4-methyl-2-oxo-2H-1-benzo
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Lu et al (2005) A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus. Proc.Natl.Acad.Sci. 102 874. PMID: 15647369.
Quynh et al (2005) Effects of galnon, a non-peptide galanin-receptor agonist, on insulin release from rat pancreatic islets. Biochem.Biophys.Res.Comm. 328 213. PMID: 15670772.
Abramov et al (2004) Regulation of feeding by galnon. Neuropeptides 38 55. PMID: 15003717.
Saar et al (2002) Anticonvulsant activity of a nonpeptide galanin receptor agonist Proc.Natl.Acad.Sci.USA 99 7136. PMID: 12011470.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses Galnon from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Galnon, supplier, Selective, non-peptide, GAL1, GalR1, agonists, Receptors, Galanin, Tocris Bioscience, Galanin Receptor Agonist products
Find multiple products by catalog number
New Products in this Area
Potent human MC1 receptor antagonist; also MC3 and MC5 partial agonistNeuropeptide S (Mouse)
Potent endogenous neuropeptide S receptor (NPSR) agonistML 382
MrgX1 (SNSR4) positive allosteric modulatorK-(D-1-Nal)-FwLL-NH2
High affinity and potent ghrelin receptor inverse agonistNeuropeptide S (Rat)
Potent endogenous neuropeptide S receptor agonistNeuropeptide S (human)
Potent endogenous neuropeptide S receptor agonist
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.