Glucagon-like peptide 1 (7-36) amide (human, rat)

Cat. No. 2082

Glucagon-like peptide 1 (7-36) amide (human, rat) His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2

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Alternative Name: GLP-1 (7-36) amide

Biological Activity

Potent glucose-dependent insulinotropic peptide produced by post-translational processing of proglucagon in intestinal L-cells. Displays high affinity for GLP-1 receptors expressed in rat insulinoma-derived RINm5F cells (Kd = 204 pM). Stimulates insulin gene transcription and secretion in pancreatic β-cells. Displays antiapoptotic effects in hippocampal neurons and reduces food intake in fasted rats following central administration.

Technical Data


(Modifications: Arg-30 = C-terminal amide)

Soluble to 1 mg/ml in water
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Perry et al (2002) Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4. J.Pharmacol.Exp.Ther. 302 881. PMID: 12183643.

Perfetti and Merkel (2000) Glucagon-like peptide-1: a major regulator of pancreatic β-cell function. Eur.J.Endocrinol. 143 717. PMID: 11124853.

Turton et al (1996) A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379 69. PMID: 8538742.

Goke and Conlon (1988) Receptors for glucagon-like peptide-1(7-37) amide on rat insulinoma-derived cells. J.Endocrinol. 116 357. PMID: 2832504.

If you know of a relevant reference for Glucagon-like peptide 1 (7-36) amide (human, rat) please let us know.

Citations are publications that use Tocris products.

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