Glucagon-like peptide 1 (7-36) amide (human, rat)
Cat. No. 2082
Alternative Name: GLP-1 (7-36) amide
Biological ActivityPotent glucose-dependent insulinotropic peptide produced by post-translational processing of proglucagon in intestinal L-cells. Displays high affinity for GLP-1 receptors expressed in rat insulinoma-derived RINm5F cells (Kd = 204 pM). Stimulates insulin gene transcription and secretion in pancreatic β-cells. Displays antiapoptotic effects in hippocampal neurons and reduces food intake in fasted rats following central administration.
(Modifications: Arg-30 = C-terminal amide)
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Perry et al (2002) Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4. J.Pharmacol.Exp.Ther. 302 881. PMID: 12183643.
Perfetti and Merkel (2000) Glucagon-like peptide-1: a major regulator of pancreatic β-cell function. Eur.J.Endocrinol. 143 717. PMID: 11124853.
Turton et al (1996) A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379 69. PMID: 8538742.
Goke and Conlon (1988) Receptors for glucagon-like peptide-1(7-37) amide on rat insulinoma-derived cells. J.Endocrinol. 116 357. PMID: 2832504.
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