PHM 27 (human)
Cat. No. 2080
Alternative Names: Peptide histidine methionine 27 (human), Human PHI 27
Biological ActivityEndogenous peptide product of human prepro-VIP and analog of porcine PHI-27; potent agonist for the human calcitonin receptor (EC50 = 11 nM). Transgenic mice expressing the human VIP/PHM 27 gene in pancreatic β-islets display enhanced glucose-induced insulin secretion.
(Modifications: Met-27 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Ma et al (2004) Discovery of novel peptide/receptor interactions: identification of PHM-27 as a potent agonist of the human calcitonin receptor. Biochem.Pharmacol. 67 1279. PMID: 15013843.
Kato et al (1994) Transgenic mice overexpressing human vasoactive intestinal peptide (VIP) gene in pancreatic β cells. J.Biol.Chem. 269 21223. PMID: 8063743.
Itoh et al (1983) Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27. Nature 304 547. PMID: 6571696.
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Keywords: PHM 27 (human), supplier, Potent, calcitonin, receptor, agonists, endogenous, human, VIP, prepro-VIP, analogue, porcine, PHI27, Receptors, Vasoactive, intestinal, peptide, PHM27, (human), Peptide, histidine, methionine27, Tocris Bioscience