RS 39604 hydrochloride
Cat. No. 0991
Chemical Name: 1-[4-Amino-5-chloro-2-(3,5-dimethox
Biological ActivityA potent and selective 5-HT4 antagonist, with a pKi of 9.1 at 5-HT4 receptors in guinea pig striatal membranes and greater than 1000-fold selectivity over 5-HT1A, 2C, 3 and D1, D2, M1, M2, AT1, B1 and α1C receptors. The ketone group gives RS 39604 a relatively long half life; it is also orally active and so suitable for in vivo studies.
Licensing InformationSold with the permission of Roche Bioscience
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Eglen et al (1995) Central 5-HT4 receptors TiPS 16 391. PMID: 8578609.
Hegde (1995) RS 39604: a potent, selective and orally active 5-HT4 receptor antagonist. Br.J.Pharmacol. 115 1087. PMID: 7582507.
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Citations are publications that use Tocris products. Selected citations for RS 39604 hydrochloride include:
Ratner et al (2012) Cerebral markers of the serotonergic system in rat models of obesity and after Roux-en-Y gastric bypass. Learn Mem 20 2133. PMID: 22450706.
Müller et al (2009) 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo. PLoS One 4 e6453. PMID: 19649285.
Huang and Kandel (2007) Low-frequency stimulation induces a pathway-specific late phase of LTP in the amygdala that is mediated by PKA and dependent on protein synthesis. J Pharmacol Exp Ther 14 497. PMID: 17626908.
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Keywords: RS 39604 hydrochloride, supplier, 5-HT4, antagonist, Serotonin, Receptors, 5-Hydroxytryptamine, RS39604, hydrochloride, Tocris Bioscience, 5-HT4 Receptor Antagonist products
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