CNQX disodium salt

Cat. No. 1045

CNQX disodium salt C9H2N4O4Na2 [479347-85-8]

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Chemical Name: 6-Cyano-7-nitroquinoxaline-2,3-dione disodium

Biological Activity

More water soluble disodium salt of the AMPA/kainate antagonist CNQX (Cat. No. 0190). Also available as part of the Kainate Receptor Tocriset™.

Technical Data

M.Wt:
276.12
Formula:
C9H2N4O4Na2
Solubility:
Soluble to 20 mM in water
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
479347-85-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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King et al (1992) Antagonism of synaptic potentials in ventral horn neurones by 6-cyano-7-nitroquinoxaline-2,3-dione: a study in the rat spinal cord in vitro. Br.J.Pharmacol. 107 375. PMID: 1358390.

Long et al (1990) Effect of 6-cyano-2,3-dihydroxy-7-nitro-quinoxaline (CNQX) on dorsal root-, NMDA-, kainate and quisqualate-mediated depolarization of rat motoneurones in vitro. Br.J.Pharmacol. 100 850. PMID: 1976402.

Watkins et al (1990) Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists. TiPS 11 25. PMID: 2155495.

Honore et al (1988) Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science 241 701. PMID: 2899909.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for CNQX disodium salt include:

Philippart et al (2016) Differential Somatic Ca2+ Channel Profile in Midbrain Dopaminergic Neurons The Journal of Neuroscience 6 7234. PMID: 27383597.

Piet et al (2016) Vasoactive Intestinal Peptide Excites GnRH Neurons in Male and Female Mice. Endocrinology. 157 3621. PMID: 27501185 .

Baltz and Voigt (2015) Interaction of electrically evoked activity with intrinsic dynamics of cultured cortical networks with and without functional fast GABAergic synaptic transmission. Front Cell Neurosci 9 272. PMID: 26236196.

Einarsson et al (2015) Systems reconsolidation reveals a selective role for the anterior cingulate cortex in generalized contextual fear memory expression. J Endocrinol 40 480. PMID: 25091528.

Schitine et al (2015) Functional plasticity of GAT-3 in avian Müller cells is regulated by neurons via a glutamatergic input. J Neurosci 82 42. PMID: 25700791.

Zhao et al (2015) Extracellular glutamate exposure facilitates group I mGluR-mediated epileptogenesis in the hippocampus. Neuropsychopharmacology 35 308. PMID: 25568123.

Schubert et al (2014) Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis. Acta Neuropathol 128 835. PMID: 25341622.

Guo et al (2012) Tissue engineering the monosynaptic circuit of the stretch reflex arc with co-culture of embryonic motoneurons and proprioceptive sensory neurons. Biomaterials 33 5723. PMID: 22594977.

Janssen et al (2012) Neuregulin directly decreases voltage-gated sodium current in hippocampal ErbB4-expressing interneurons. J Neurosci 32 13889. PMID: 23035098.

Yuan et al (2009) The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-methyl-D-aspartate receptors. J Biol Chem 284 12862. PMID: 19240037.

Do you know of a great paper that uses CNQX disodium salt from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: CNQX disodium salt, supplier, water, soluble, Glutamate, AMPA, Receptors, iGlur, Ionotropic, Kainate, antagonists, Tocris Bioscience, AMPA Receptor Antagonist products

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