CNQX disodium salt
Cat. No. 1045
Chemical Name: 6-Cyano-7-nitroquinoxaline-2,3-dion
Biological ActivityMore water soluble disodium salt of the AMPA/kainate antagonist CNQX (Cat. No. 0190). Also available as part of the Kainate Receptor Tocriset™.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
King et al (1992) Antagonism of synaptic potentials in ventral horn neurones by 6-cyano-7-nitroquinoxaline-2,3-dione: a study in the rat spinal cord in vitro. Br.J.Pharmacol. 107 375. PMID: 1358390.
Long et al (1990) Effect of 6-cyano-2,3-dihydroxy-7-nitro-quinoxaline (CNQX) on dorsal root-, NMDA-, kainate and quisqualate-mediated depolarization of rat motoneurones in vitro. Br.J.Pharmacol. 100 850. PMID: 1976402.
Watkins et al (1990) Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists. TiPS 11 25. PMID: 2155495.
Honore et al (1988) Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists. Science 241 701. PMID: 2899909.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for CNQX disodium salt include:
Philippart et al (2016) Differential Somatic Ca2+ Channel Profile in Midbrain Dopaminergic Neurons The Journal of Neuroscience 6 7234. PMID: 27383597.
Baltz and Voigt (2015) Interaction of electrically evoked activity with intrinsic dynamics of cultured cortical networks with and without functional fast GABAergic synaptic transmission. Front Cell Neurosci 9 272. PMID: 26236196.
Schubert et al (2014) Paraneoplastic CDR2 and CDR2L antibodies affect Purkinje cell calcium homeostasis. Acta Neuropathol 128 835. PMID: 25341622.
Guo et al (2012) Tissue engineering the monosynaptic circuit of the stretch reflex arc with co-culture of embryonic motoneurons and proprioceptive sensory neurons. Biomaterials 33 5723. PMID: 22594977.
Janssen et al (2012) Neuregulin directly decreases voltage-gated sodium current in hippocampal ErbB4-expressing interneurons. J Neurosci 32 13889. PMID: 23035098.
Yuan et al (2009) The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-methyl-D-aspartate receptors. J Biol Chem 284 12862. PMID: 19240037.
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Keywords: CNQX disodium salt, supplier, water, soluble, Glutamate, AMPA, Receptors, iGlur, Ionotropic, Kainate, antagonists, Tocris Bioscience, AMPA Receptor Antagonist products
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