Cat. No. 2078
Chemical Name: (RS)-1-(2-Amino-2-carboxyethyl)-3-(
Biological ActivitySelective GluR5-subunit containing kainate receptor antagonist (apparent KD = 1.09 μM). Displays ~ 90-fold selectivity over AMPA receptors and recombinant human GluR6- and KA2-containing kainate receptors. Has little or no action at NMDA or group I mGlu receptors. Selectively blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibers. Active enantiomer UBP 302 (Cat. No. 2079) available.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Dolman et al (2005) Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors. J.Med.Chem. 48 7867. PMID: 16302825.
More et al (2004) Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist. Neuropharmacology 47 46. PMID: 15165833.
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Citations are publications that use Tocris products. Selected citations for UBP 296 include:
Albiñana et al (2015) Chondroitin Sulfate Induces Depression of Synaptic Transmission and Modulation of Neuronal Plasticity in Rat Hippocampal Slices. Neural Plast 2015 463854. PMID: 26075099.
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Keywords: UBP 296, supplier, Selective, potent, kainate, antagonists, selective, GluR5-containing, receptors, Glutamate, Kainate, Receptors, iGluR, Ionotropic, UBP296, Tocris Bioscience, Kainate Receptor Antagonist products