Cat. No. 2077
Chemical Name: N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hy
Biological ActivityProdrug of the Kir6 (KATP) channel opener Y-26763 (Cat. No. 2076). Inactive in vitro; fails to modify tension in contracted aortic rings at concentrations up to 1 mM. Produces long-lasting antihypertensive effects in vivo, with minimal tachycardia following oral administration in hypertensive animals.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Fukunari et al (1997) Y-26763 protects the canine heart from a stunning injury through opening of the KATP channels. Eur.J.Pharmacol. 323 197. PMID: 9128839.
Nakajima et al (1992) Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state. J.Pharmacol.Exp.Ther. 261 730. PMID: 1578381.
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Keywords: Y-27152, supplier, Prodrug, KATP, channels, openers, Y-26763, orally, active, vivo, potassium, KIR, Inward, Rectifier, K+, Kir6, Tocris Bioscience, Inward Rectifier Potassium (Kir) Channel Activator products