Y-27152

Cat. No. 2077

Y-27152 C21H22N2O4 [127408-30-4]

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Chemical Name: N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-(phenylmethoxy)acetamide

Biological Activity

Prodrug of the Kir6 (KATP) channel opener Y-26763 (Cat. No. 2076). Inactive in vitro; fails to modify tension in contracted aortic rings at concentrations up to 1 mM. Produces long-lasting antihypertensive effects in vivo, with minimal tachycardia following oral administration in hypertensive animals.

Technical Data

M.Wt:
366.41
Formula:
C21H22N2O4
Solubility:
Soluble to 5 mM in ethanol with gentle warming and to 25 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
127408-30-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Fukunari et al (1997) Y-26763 protects the canine heart from a stunning injury through opening of the KATP channels. Eur.J.Pharmacol. 323 197. PMID: 9128839.

Nakajima et al (1992) Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state. J.Pharmacol.Exp.Ther. 261 730. PMID: 1578381.

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Keywords: Y-27152, supplier, Prodrug, KATP, channels, openers, Y-26763, orally, active, vivo, potassium, KIR, Inward, Rectifier, K+, Kir6, Tocris Bioscience, Inward Rectifier Potassium (Kir) Channel Activator products

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