Cat. No. 2076
Chemical Name: N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hy
Biological ActivityKir6 (KATP) channel opener and active metabolite of Y-27152 (Cat. No. 2077). Relaxes contracted rat aortic rings (IC50 = 0.027 mM) and inhibits glucose-induced insulin secretion in isolated human pancreatic β-cells in vitro. Produces hypotension in spontaneously hypertensive rats and displays cardioprotective properties in dogs following systemic administration in vivo.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Cosgrove et al (2004) Y-26763: ATP-sensitive K+ channel activation and the inhibition of insulin release from human pancreatic β-cells Eur.J.Pharmacol. 486 133. PMID: 14975702.
Fukunari et al (1997) Y-26763 protects the canine heart from a stunning injury through opening of the KATP channels Eur.J.Pharmacol. 323 197. PMID: 9128839.
Nakajima et al (1992) Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state. J.Pharmacol.Exp.Ther. 261 730. PMID: 1578381.
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Keywords: Y-26763, supplier, KATP, channel, openers, Potassium, KIR, Inward, Rectifier, K+, Kir6, Tocris Bioscience, Inward Rectifier Potassium (Kir) Channel Activator products