Y-26763

Cat. No. 2076

Y-26763 C14H16N2O4 [127408-31-5]

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Chemical Name: N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-hydroxyacetamide

Biological Activity

Kir6 (KATP) channel opener and active metabolite of Y-27152 (Cat. No. 2077). Relaxes contracted rat aortic rings (IC50 = 0.027 mM) and inhibits glucose-induced insulin secretion in isolated human pancreatic β-cells in vitro. Produces hypotension in spontaneously hypertensive rats and displays cardioprotective properties in dogs following systemic administration in vivo.

Technical Data

M.Wt:
276.29
Formula:
C14H16N2O4
Solubility:
Soluble to 100 mM in 1eq. NaOH
Purity:
>98 %
Storage:
Store at RT
CAS No:
127408-31-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Cosgrove et al (2004) Y-26763: ATP-sensitive K+ channel activation and the inhibition of insulin release from human pancreatic β-cells Eur.J.Pharmacol. 486 133. PMID: 14975702.

Fukunari et al (1997) Y-26763 protects the canine heart from a stunning injury through opening of the KATP channels Eur.J.Pharmacol. 323 197. PMID: 9128839.

Nakajima et al (1992) Y-27152, a long-acting K+ channel opener with less tachycardia: antihypertensive effects in hypertensive rats and dogs in conscious state. J.Pharmacol.Exp.Ther. 261 730. PMID: 1578381.

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Keywords: Y-26763, supplier, KATP, channel, openers, Potassium, KIR, Inward, Rectifier, K+, Kir6, Tocris Bioscience, Inward Rectifier Potassium (Kir) Channel Activator products

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