SKF 83822 hydrobromide
Cat. No. 2075
Chemical Name: 6-Chloro-2,3,4,5-tetrahydro-1-(3-me
Biological ActivityHigh affinity, selective dopamine D1-like receptor agonist. Ki values are 3.2, 3.1, 186, 66, 335, 1167, 1251 and 1385 nM at recombinant D1, D5, D2, D3, D4, 5-HT2A, α1A and α1B receptors respectively. Stimulates adenylyl cyclase (EC50 = 65 nM) but not phosphoinositide hydrolysis. Induces extreme arousal and hyperlocomotion following subcutaneous administration in monkeys.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
O'Sullivan et al (2004) SK&F 83822 distinguishes adenylyl cyclase from phospholipase C-coupled D1-like receptors: behavioural topography. Eur.J.Pharmacol. 486 273. PMID: 14985049.
Peacock and Gerlach (2001) Aberrant behavioural effects of a dopamine D1 receptor antagonist and agonist in monkeys: evidence of uncharted dopamine D1 receptor actions. Biol.Psychiatry 50 501. PMID: 11600103.
Undie et al (1994) Evidence for a distinct D1-like dopamine receptor that couples to activation of phosphoinositide metabolism in brain. J.Neurochem. 62 2045. PMID: 7908949.
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Citations are publications that use Tocris products. Selected citations for SKF 83822 hydrobromide include:
Kramar et al (2014) Dopamine in the dorsal hippocampus impairs the late consolidation of cocaine-associated memory. J Neurosci 39 1645. PMID: 24442095.
Ruskin et al (2013) Ketogenic diet improves core symptoms of autism in BTBR mice. PLoS One 8 e65021. PMID: 23755170.
Urizar et al (2011) CODA-RET reveals functional selectivity as a result of GPCR heteromerization. Neuropsychopharmacology 7 624. PMID: 21785426.
Do you know of a great paper that uses SKF 83822 hydrobromide from Tocris? If so please let us know.
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