SKF 83959 hydrobromide

Cat. No. 2074

SKF 83959 hydrobromide C18H20ClNO2.HBr [67287-95-0]

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Chemical Name: 6-Chloro-2,3,4,5-tetrahydro-3-methyl-1-(3-methylphenyl)-1H-3-benzazepine-7,8-diol

Biological Activity

Dopamine D1-like receptor partial agonist (Ki values are 1.18, 7.56, 920 and 399 nM for rat D1, D5, D2 and D3 receptors respectively). May act as an antagonist in vivo, producing anti-Parkinsonian effects and antagonizing the behavioral effects of cocaine. Shown to potentiate agonist binding of the σ1 receptor.

Technical Data

M.Wt:
398.73
Formula:
C18H20ClNO2.HBr
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at RT
CAS No:
67287-95-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Guo et al (2013) SKF83959 is a potent allosteric modulator of sigma-1 receptor. Mol.Pharmacol. 83 577. PMID: 23295385.

Neumeyer et al (2003) Receptor affinities of dopamine D1 receptor-selective novel phenylbenzazepines. Eur.J.Pharmacol. 474 137. PMID: 12921854.

Cools et al (2002) SKF 83959 is an antagonist of dopamine D1-like receptors in the prefrontal cortex and nucleus accumbens: a key to its antiparkinsonian effect in animals? Neuropharmacology 42 237. PMID: 11804620.

Platt et al (2000) Dissociation of cocaine-antagonist properties and motoric effects of the D1 receptor partial agonists SKF 83959 and SKF 77434. J.Pharmacol.Exp.Ther. 293 1017. PMID: 10869406.

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Citations are publications that use Tocris products. Selected citations for SKF 83959 hydrobromide include:

Perreault et al (2013) A physiological role for the dopamine D5 receptor as a regulator of BDNF and Akt signalling in rodent prefrontal cortex. Int J Neuropsychopharmacol 16 477. PMID: 22827965.

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Keywords: SKF 83959 hydrobromide, supplier, D1-like, partial, agonists, Dopamine, D1, Receptors, D5, dopaminergic, SKF83959, hydrobromide, Tocris Bioscience, D1 and D5 Receptor Agonist products

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