SKF 83959 hydrobromide
Cat. No. 2074
Chemical Name: 6-Chloro-2,3,4,5-tetrahydro-3-methy
Biological ActivityDopamine D1-like receptor partial agonist (Ki values are 1.18, 7.56, 920 and 399 nM for rat D1, D5, D2 and D3 receptors respectively). May act as an antagonist in vivo, producing anti-Parkinsonian effects and antagonizing the behavioral effects of cocaine. Shown to potentiate agonist binding of the σ1 receptor.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Guo et al (2013) SKF83959 is a potent allosteric modulator of sigma-1 receptor. Mol.Pharmacol. 83 577. PMID: 23295385.
Neumeyer et al (2003) Receptor affinities of dopamine D1 receptor-selective novel phenylbenzazepines. Eur.J.Pharmacol. 474 137. PMID: 12921854.
Cools et al (2002) SKF 83959 is an antagonist of dopamine D1-like receptors in the prefrontal cortex and nucleus accumbens: a key to its antiparkinsonian effect in animals? Neuropharmacology 42 237. PMID: 11804620.
Platt et al (2000) Dissociation of cocaine-antagonist properties and motoric effects of the D1 receptor partial agonists SKF 83959 and SKF 77434. J.Pharmacol.Exp.Ther. 293 1017. PMID: 10869406.
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Citations are publications that use Tocris products. Selected citations for SKF 83959 hydrobromide include:
Cassar et al (2015) A dopamine receptor contributes to paraquat-induced neurotoxicity in Drosophila. Pharmacol Biochem Behav 24 197. PMID: 25158689.
Shen et al (2015) The dopamine D1-D2 receptor heteromer exerts a tonic inhibitory effect on the expression of amphetamine-induced locomotor sensitization. Br J Pharmacol 128 33. PMID: 25444866.
Fuenzalida et al (2014) Dopamine D1 and corticotrophin-releasing hormone type-2α receptors assemble into functionally interacting complexes in living cells. PLoS One 171 5650. PMID: 25073922.
Perreault et al (2013) A physiological role for the dopamine D5 receptor as a regulator of BDNF and Akt signalling in rodent prefrontal cortex. Int J Neuropsychopharmacol 16 477. PMID: 22827965.
Huang et al (2012) SKF83959, an agonist of phosphatidylinositol-linked D(1)-like receptors, promotes ERK1/2 activation and cell migration in cultured rat astrocytes. Nat Chem Biol 7 e49954. PMID: 23185493.
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Keywords: SKF 83959 hydrobromide, supplier, D1-like, partial, agonists, Dopamine, D1, Receptors, D5, dopaminergic, SKF83959, hydrobromide, Tocris Bioscience, D1 and D5 Receptor Agonist products