Antisauvagine-30

Cat. No. 2071

Antisauvagine-30 D-Phe-His-Leu-Leu-Arg-Lys-Met-Ile-Glu-Ile-Glu-Lys-Gln-Glu-Lys-Glu-Lys-Gln-Gln-Ala-Ala-Asn-Asn-Arg-Leu-Leu-Leu-Asp-Thr-Ile-NH2

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Alternative Name: [D-Phe11,His12]-Sauvagine (11-40)

Biological Activity

Potent, selective and competitive corticotropin-releasing factor CRF2 receptor antagonist (Kd values are 1.4 and 153.6 nM for binding to mouse CRF2β and rat CRF1 receptors respectively). Inhibits sauvagine-stimulated cAMP accumulation in HEK-mCRF2β cells (pA2 = 8.49). Prevents stress-enhanced fear conditioning and MEK 1/2-dependent activation of ERK1/2 in mice in vivo.

Licensing Information

Sold with the permission of the Max Planck Institute

Technical Data

M.Wt:
3650.29
Formula:
C161H274N48O46S
Sequence:
FHLLRKMIEIEKQEKEKQQAANNRLLLDTI

(Modifications: Phe-1 = D-Phe, Ile-30 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
220673-95-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Sananbenesi et al (2003) Mitogen-activated protein kinase signaling in the hippocampus and its modulation by corticotropin-releasing factor receptor 2: a possible link between stress and fear memory. J.Neurosci. 23 11436. PMID: 14673008.

Brauns et al (2001) Pharmacological and chemical properties of astressin, antisauvagine-30 and α-helCRF: significance for behavioral experiments. Neuropharmacology 41 507. PMID: 11543771.

Ruhmann et al (1998) Structural requirements for peptidic antagonists of the corticotropin-releasing factor receptor (CRFR): development of CRFR2β-selective antisauvagine-30. Proc.Natl.Acad.Sci.USA 95 15264.

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Keywords: Antisauvagine-30, supplier, Potent, selective, competitive, CRF2, antagonists, Corticotropin-Releasing, Factor2, Receptors, Tocris Bioscience, CRF2 Receptor Antagonist products

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