Cat. No. 2071
Alternative Name: [D-Phe11,His12]-Sauvagine (11-40)
Biological ActivityPotent, selective and competitive corticotropin-releasing factor CRF2 receptor antagonist (Kd values are 1.4 and 153.6 nM for binding to mouse CRF2β and rat CRF1 receptors respectively). Inhibits sauvagine-stimulated cAMP accumulation in HEK-mCRF2β cells (pA2 = 8.49). Prevents stress-enhanced fear conditioning and MEK 1/2-dependent activation of ERK1/2 in mice in vivo.
Licensing InformationSold with the permission of the Max Planck Institute
(Modifications: Phe-1 = D-Phe, Ile-30 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Sananbenesi et al (2003) Mitogen-activated protein kinase signaling in the hippocampus and its modulation by corticotropin-releasing factor receptor 2: a possible link between stress and fear memory. J.Neurosci. 23 11436. PMID: 14673008.
Brauns et al (2001) Pharmacological and chemical properties of astressin, antisauvagine-30 and α-helCRF: significance for behavioral experiments. Neuropharmacology 41 507. PMID: 11543771.
Ruhmann et al (1998) Structural requirements for peptidic antagonists of the corticotropin-releasing factor receptor (CRFR): development of CRFR2β-selective antisauvagine-30. Proc.Natl.Acad.Sci.USA 95 15264.
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Citations are publications that use Tocris products. Selected citations for Antisauvagine-30 include:
Narla et al (2015) Suppression of piriform cortex activity in rat by corticotropin-releasing factor 1 and serotonin 2A/C receptors. Hum Mol Genet 9 200. PMID: 26074770.
Zhao-Shea et al (2015) Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal. Front Cell Neurosci 6 6770. PMID: 25898242.
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Keywords: Antisauvagine-30, supplier, Potent, selective, competitive, CRF2, antagonists, Corticotropin-Releasing, Factor2, Receptors, Tocris Bioscience, CRF2 Receptor Antagonist products
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