K 41498

Cat. No. 2070

K 41498 D-Phe-His-Leu-Leu-Arg-Lys-Nle-Ile-Glu-Ile-Glu-Lys-Gln-Glu-Lys-Glu-Lys-Gln-Gln-Ala-Ala-Asn-Asn-Arg-Leu-Leu-Leu-Asp-Thr-Ile-NH2

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Biological Activity

Potent and highly selective CRF2 receptor antagonist (Ki values are 0.66, 0.62 and 425 nM for human CRF2α, CRF2β and CRF1 receptors respectively). Inhibits sauvagine-stimulated cAMP accumulation in hCRF2α- and hCRF2β-expressing cells. In rats in vivo, blocks urocortin-induced hypotension following systemic administration.

Licensing Information

Sold with the permission of the Max Planck Institute

Technical Data

M.Wt:
3632.26
Formula:
C162H276N48O46
Sequence:
FHLLRKXIEIEKQEKEKQQAANNRLLLDTI

(Modifications: Phe-1 = D-Phe, X = Nle, Ile-30 = C-terminal amide)

Solubility:
Soluble to 5 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
434938-41-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Lawrence et al (2002) The highly selective CRF2 receptor antagonist K41498 binds to presynaptic CRF2 receptors in rat brain. Br.J.Pharmacol. 136 896. PMID: 12110614.

Ruhmann et al (2002) Design, synthesis and pharmacological characterization of new highly selective CRF2 antagonists: development of 123I-K31440 as a potential SPECT ligand. Peptides 23 453. PMID: 11835994.

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Keywords: K 41498, supplier, selective, potent, CRF2, antagonists, Corticotropin-Releasing, Factor2, Receptors, K41498, Tocris Bioscience, CRF2 Receptor Antagonist products

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