187-1, N-WASP inhibitor

Cat. No. 2067

187-1, N-WASP inhibitor cyclo(Lys-D-Phe-D-Pro-D-Phe-Phe-D-Pro-Gln)2

Price and Availability

For 187-1, N-WASP inhibitor pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Biological Activity

Inhibits neural Wiskott-Aldrich syndrome protein (N-WASP) by stabilizing the autoinhibited state of the protein. Blocks phosphatidylinositol 4,5-bisphosphate (PIP2)-stimulated actin assembly (IC50 ~ 2 μM) but does not directly inhibit actin polymerization.

Technical Data

M.Wt:
1784.13
Formula:
C96H122N18O16
Sequence:
KFPFFPQ KFPFFPQ

(Modifications: Phe-2 = D-Phe, Pro-3 = D-Pro, Phe-4 = D-Phe, Pro-6 = D-Pro, Cyclized)

Solubility:
Soluble to 2 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
380488-27-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

Prehoda and Lim (2002) How signaling proteins integrate multiple inputs: a comparison of N-WASP and cdk2. Curr.Opin.Cell Biol. 14 149. PMID: 11891112.

Peterson et al (2001) A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions. Proc.Natl.Acad.Sci.USA 98 10624.

Suetsugu et al (2001) Identification of another actin-related (Arp) 2/3 complex binding site in neural Wiskott-Aldrich syndrome protein (N-WASP) that complements actin polymerization induced by the Arp2/3 complex activating (VCA) domain of N-WASP. J.Biol.Chem. 276 33175. PMID: 11432863.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses 187-1, N-WASP inhibitor from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: 187-1, N-WASP inhibitor, supplier, inhibitors, inhibits, actin, assembly, neural, Wiskott-Aldrich, syndrome, protein, Tocris Bioscience, Actin Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Bio-Techne Events

Neuroscience 2016

Neuroscience 2016

November 12 - 16, 2016

San Diego, CA, USA

Booth: 3217