4-Acetyl-1,1-dimethylpiperazinium iodide

Cat. No. 0352

4-Acetyl-1,1-dimethylpiperazinium iodide C8H17IN2O [75667-84-4]

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Biological Activity

Structural analog of acetylcholine that acts as a nicotinic agonist (Ki = 29.9 nM at α4β2). Upregulates the number of α4β2 binding sites in M10 cells in vitro by 440%.

Technical Data

M.Wt:
284.14
Formula:
C8H17IN2O
Solubility:
Soluble to 100 mM in water
Storage:
Store at RT
CAS No:
75667-84-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Warpman et al (1998) Regulation of nicotinic receptor subtypes following chronic nicotinic agonist exposure in M10 and SH-SY5Y neuroblastoma cells. J.Neurochem. 70 2028. PMID: 9572289.

Spivak et al (1988) Binding of semirigid nicotinic agonists to nicotinic and muscarinic receptors. Mol.Pharmacol. 36 177. PMID: 2747625.

Spivak et al (1986) Structural and electronic requirements for potent agonists at a nicotinic receptor. Eur.J.Pharmacol. 120 127. PMID: 3485051.

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Keywords: 4-Acetyl-1,1-dimethylpiperazinium iodide, supplier, Nicotinic, agonists, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, Acetyldimethylpiperazinium, Tocris Bioscience, Nicotinic Receptor (Non-selective) Agonist products

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