Cat. No. 0391
Alternative Name: α-NAAG
Chemical Name: N-Acetyl-L-aspartyl-L-glutamic acid
Biological ActivityThe most abundant peptide neurotransmitter in the mammalian CNS. A weak activator of NMDA receptors, and a highly selective agonist for mGlu3 receptors. Neuroprotective under non-hydrolysing conditions in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Neale et al (2000) N-Acetylaspartylglutamate: the most abundant peptide neurotransmitter in the mammalian central nervous system. J.Neurochem. 75 443. PMID: 10899918.
Thomas et al (2000) N-Acetylated α-linked acidic dipeptidase converts N-acetylaspartylglutamate from a neuroprotectant to a neurotoxin. J.Pharmacol.Exp.Ther. 295 16. PMID: 10991955.
Wroblewska et al (1997) N-Acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells. J.Neurochem. 69 174. PMID: 9202308.
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Citations are publications that use Tocris products. Selected citations for Spaglumic acid include:
Kolodziejczyk et al (2009) The effect of N-acetyl-aspartyl-glutamate and N-acetyl-aspartate on white matter oligodendrocytes. Brain 132 1496. PMID: 19383832.
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Keywords: Spaglumic acid, supplier, Putative, endogenous, neurotransmitter, Selective, mGlu3, agonists, Glutamate, mGlur, Receptors, Metabotropic, Group, II, iGluR, Ionotropic, alpha-NAAG, NAAG, Tocris Bioscience, Glutamate (Metabotropic) Group II Receptor Agonist products