Spaglumic acid

Cat. No. 0391

Spaglumic acid C11H16N2O8 [3106-85-2]

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Alternative Name: α-NAAG

Chemical Name: N-Acetyl-L-aspartyl-L-glutamic acid

Biological Activity

The most abundant peptide neurotransmitter in the mammalian CNS. A weak activator of NMDA receptors, and a highly selective agonist for mGlu3 receptors. Neuroprotective under non-hydrolysing conditions in vivo.

Technical Data

M.Wt:
304.26
Formula:
C11H16N2O8
Solubility:
Soluble to 100 mM in water
Purity:
>96 %
Storage:
Store at -20°C
CAS No:
3106-85-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Neale et al (2000) N-Acetylaspartylglutamate: the most abundant peptide neurotransmitter in the mammalian central nervous system. J.Neurochem. 75 443. PMID: 10899918.

Thomas et al (2000) N-Acetylated α-linked acidic dipeptidase converts N-acetylaspartylglutamate from a neuroprotectant to a neurotoxin. J.Pharmacol.Exp.Ther. 295 16. PMID: 10991955.

Wroblewska et al (1997) N-Acetylaspartylglutamate selectively activates mGluR3 receptors in transfected cells. J.Neurochem. 69 174. PMID: 9202308.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Spaglumic acid include:

Kolodziejczyk et al (2009) The effect of N-acetyl-aspartyl-glutamate and N-acetyl-aspartate on white matter oligodendrocytes. Brain 132 1496. PMID: 19383832.

Do you know of a great paper that uses Spaglumic acid from Tocris? If so please let us know.

Keywords: Spaglumic acid, supplier, Putative, endogenous, neurotransmitter, Selective, mGlu3, agonists, Glutamate, mGlur, Receptors, Metabotropic, Group, II, iGluR, Ionotropic, alpha-NAAG, NAAG, Tocris Bioscience, Glutamate (Metabotropic) Group II Receptor Agonist products

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