Cat. No. 0722

N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide C10H10ClNO5S [142867-52-5]

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Biological Activity

A pro-drug of the potent vasorelaxant nitroxyl, H-N=O, which it slowly releases in neutral solution. HNO eventually dimerizes and dehydrates to N2O, without producing NO. Also a powerful inhibitor of aldehyde dehydrogenase.

Technical Data

Soluble to 100 mM in DMSO
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Fukuto et al (1992) N,O-Diacylated-N-hydroxyarylsulfonamides: nitroxyl precursors with potent smooth muscle relaxant properties. Biochem.Biophys.Res.Commun. 187 1367. PMID: 1417812.

Lee et al (1992) Prodrugs of nitroxyl as inhibitors of aldehyde dehydrogenase. J.Med.Chem. 35 3648. PMID: 1433175.

If you know of a relevant reference for N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide please let us know.

Citations are publications that use Tocris products.

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Keywords: N-Acetyl-N-acetoxy-4-chlorobenzenesulfonamide, supplier, Nitroxyl, precursor, ROS, Donors, NO, Precursors, Nitric, Oxide, Signaling, Signalling, Tocris Bioscience, NO Donors / Precursor products

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