Cat. No. 2038

Iloprost C22H32O4 [78919-13-8]

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Alternative Name: ZK 36374

Chemical Name: (5E)-5-[(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyl-1-octen-6-ynyl]-2(1H)-pentalenylidene]pentanoic acid

Biological Activity

Prostacyclin (PGI2) analog that binds with high affinity to IP, EP1 and EP3 receptors (Ki values are 11, 11, 56, 284, 619, 1035, 1870 and 6487 nM for IP, EP1, EP3, EP4, FP, DP, EP2 and TP receptors respectively). Inhibits platelet aggregation induced by collagen, thrombin and ADP (IC50 values are 0.24, 0.71 and 1.07 nM respectively).

Technical Data

Soluble in methyl acetate (supplied pre-dissolved - 5mg/ml)
>97 %
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Della Bella et al (2001) Novel mode of action of iloprost: in vitro down-regulaton of endothelial cell adhesion molecules. Prostaglandins Other Lipid Mediat. 65 73. PMID: 11403500.

Abramovitz et al (2000) The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim.Biophys.Acta 1483 285. PMID: 10634944.

Schror et al (1981) The antiplatelet and cardiovascular actions of a new carbacyclin derivative (ZK 36 374) - equipotent to PGI2 in vitro. Naunyn-Schmied.Arch.Pharmacol. 316 252.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Iloprost include:

Lee and Diamond (2015) A human platelet calcium calculator trained by pairwise agonist scanning. Nat Commun 11 e1004118. PMID: 25723389.

Flamm et al (2012) Multiscale prediction of patient-specific platelet function under flow. Blood 120 190. PMID: 22517902.

Do you know of a great paper that uses Iloprost from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Iloprost, supplier, Prostacyclin, PGI2, IP, EP1, EP3, Receptors, Prostaglandin, Prostanoid, prostaglandins, prostacyclins, eicosanoids, ZK36374, Tocris Bioscience, Prostanoid Receptor Agonist products

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