BWX 46

Cat. No. 2035

BWX 46 Tyr-Ile-Asn-Leu-Cys-Thr-Arg-Nva-Arg-Tyr-NH2 Tyr-Ile-Asn-Leu-Cys-Thr-Arg-Nva-Arg-Tyr-NH2 (Disulfide bridge: 5-5*)

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Alternative Name: Bis(31/31'){Cys31, Nva34]NPY(27-36)-NH2}

Biological Activity

Potent and highly selective NPY Y5 receptor agonist (Ki values are 0.85, 42, 3015 and 245 nM at Y5, Y1, Y2 and Y4 receptors respectively). Stimulates food intake gradually following intrahypothalamic administration in rats.

Technical Data

M.Wt:
2597.09
Formula:
C116H186N36O28S2
Sequence:
YINLCTRXRY YINLCTRXRY*

(Modifications: X = Nva, Tyr-10 = C-terminal amide, X* = Nva, Tyr-10* = C-terminal amide, Disulfide bridge between 5 - 5*)

Solubility:
Soluble to 10 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
172997-92-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Balasubramaniam et al (2002) Bis(31/31'){Cys31, Nva34]NPY(27-36)-NH2}: a neuropeptide Y (NPY) Y5 receptor selective agonist with a latent stimulatory effect on food intake in rats. Peptides 23 1485. PMID: 12182951.

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Keywords: BWX 46, supplier, selective, Y5, agonists, Neuropeptide, Y, Receptors, NPY, BWX46, neuropeptides, Tocris Bioscience, NPY Receptor Agonist products

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