Pentostatin

Cat. No. 2033

Pentostatin C11H16N4O4 [53910-25-1]

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Alternative Name: Deoxycoformycin

Chemical Name: (8R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol

Biological Activity

Irreversible inhibitor of adenosine deaminase (Ki = 2.5 pM). Anticancer agent.

Technical Data

M.Wt:
268.27
Formula:
C11H16N4O4
Solubility:
Soluble to 100 mM in water and to 75 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
53910-25-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Nabhan et al (2004) Purine nucleoside analogues and combination therapies in B-cell chronic lymphocytic leukemia: dawn of a new era. Leukemia Res. 28 429.

Klohs and Kraker (1992) Pentostatin: future directions. Pharmacol.Rev. 44 459. PMID: 1480666.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Pentostatin include:

Ledderose et al (2016) Adenosine arrests breast cancer cell motility by A3 receptor stimulation. Purinergic Signalling. PMID: 27577957.

Li et al (2015) Inhibition of adenosine deaminase (ADA)-mediated metabolism of cordycepin by natural substances. PLoS Comput Biol 3 e00121. PMID: 26038697.

Do you know of a great paper that uses Pentostatin from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Pentostatin, supplier, adenosines, deaminases, inhibitors, inhibits, antimetabolites, chemotherapeutics, Tocris Bioscience, Deaminase Inhibitor products

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