Cat. No. 2033
Alternative Name: Deoxycoformycin
Chemical Name: (8R)-3-(2-Deoxy-β-D-erythro-pentofur
Biological ActivityIrreversible inhibitor of adenosine deaminase (Ki = 2.5 pM). Anticancer agent.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Nabhan et al (2004) Purine nucleoside analogues and combination therapies in B-cell chronic lymphocytic leukemia: dawn of a new era. Leukemia Res. 28 429.
Klohs and Kraker (1992) Pentostatin: future directions. Pharmacol.Rev. 44 459. PMID: 1480666.
If you know of a relevant reference for Pentostatin please let us know.
Citations are publications that use Tocris products. Selected citations for Pentostatin include:
Ledderose et al (2016) Adenosine arrests breast cancer cell motility by A3 receptor stimulation. Purinergic Signalling. PMID: 27577957.
Li et al (2015) Inhibition of adenosine deaminase (ADA)-mediated metabolism of cordycepin by natural substances. PLoS Comput Biol 3 e00121. PMID: 26038697.
Do you know of a great paper that uses Pentostatin from Tocris? If so please let us know.
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Keywords: Pentostatin, supplier, adenosines, deaminases, inhibitors, inhibits, antimetabolites, chemotherapeutics, Tocris Bioscience, Deaminase Inhibitor products
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