ROS 234 dioxalate

Cat. No. 2034

ROS 234 dioxalate C13H15N5.2C2H2O4 [184576-87-2]

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Chemical Name: N-[3-(1H-Imidazol-4-yl)propyl]-1H-benzimidazol-2-amine dioxalate

Biological Activity

Potent H3 antagonist (pKB at guinea-pig ileum H3-receptor = 9.46). Limited blood brain barrier permeability (ED50 = 19.12 mg/kg i.p.).

Technical Data

M.Wt:
421.37
Formula:
C13H15N5.2C2H2O4
Solubility:
Soluble to 50 mM in water and to 50 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
184576-87-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Mor et al (2004) Synthesis, biological activity, QSAR and QSPR study of 2-aminobenzimidazole derivatives as potent H3-antagonists. Bioorg.Med.Chem.Lett. 12 663.

Ballabeni et al (2002) CNS access of selected H3-antagonists: ex vivo binding study in rats. Inflamm.Res. 51 (Suppl 1) S55. PMID: 12013409.

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Keywords: ROS 234 dioxalate, supplier, Potent, H3, antagonists, Receptors, Histamine, histaminergic, ROS234, dioxalate, Tocris Bioscience, Histamine H3 Receptor Antagonist products

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