PACMA 31

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Cat.No. 5116 - PACMA 31 | C21H22N2O6S | CAS No. 1401089-31-3
说明: Irreversible protein disulfide isomerase (PDI) inhibitor
化学名: N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycylglycine ethyl ester
纯度: ≥99% (HPLC)
说明书
引用文献
评论
文献 (5)

生物活性 for PACMA 31

PACMA 31 is an irreversible protein disulfide isomerase (PDI) inhibitor; inhibits growth of ovarian cancer cells. Suppresses tumor growth in a mouse xenograph model of human ovarian cancer.

化合物库 for PACMA 31

PACMA 31 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for PACMA 31

分子量 430.47
公式 C21H22N2O6S
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 1401089-31-3
PubChem ID 66555902
InChI Key AHOOZADJPNUFOQ-UHFFFAOYSA-N
Smiles O=C(C#C)N(C(C2=CC=CS2)C(NCC(OCC)=O)=O)C1=CC=C(OC)C=C1OC

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PACMA 31

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 43.05 100

制备储备液 for PACMA 31

以下数据基于产品分子量 430.47。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.32 mL 11.62 mL 23.23 mL
5 mM 0.46 mL 2.32 mL 4.65 mL
10 mM 0.23 mL 1.16 mL 2.32 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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参考文献 for PACMA 31

参考文献是支持产品生物活性的出版物。

Ge et al (2013) Small molecule probe suitable for in situ profiling and inhibition of protein disulfide isomerase. ACS.Chem.Biol. 8 2577 PMID: 24070012

Xu et al (2012) Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment. Proc.Natl.Acad.Sci.U.S.A. 109 16348 PMID: 22988091


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关键词: PACMA 31, PACMA 31 supplier, PACMA31, irreversible, protein, disulfide, isomerases, PDI, inhibitors, inhibits, ovarian, cancer, Protein, Disulfide, Isomerase, 5116, Tocris Bioscience

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