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Cat.No. 5116 - PACMA 31 | C21H22N2O6S | CAS No. 1401089-31-3
说明: Irreversible protein disulfide isomerase (PDI) inhibitor
化学名: N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycylglycine ethyl ester
纯度: ≥99% (HPLC)
文献 (5)

生物活性 for PACMA 31

PACMA 31 is an irreversible protein disulfide isomerase (PDI) inhibitor; inhibits growth of ovarian cancer cells. Suppresses tumor growth in a mouse xenograph model of human ovarian cancer.

化合物库 for PACMA 31

PACMA 31 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for PACMA 31

分子量 430.47
公式 C21H22N2O6S
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 1401089-31-3
PubChem ID 66555902
Smiles O=C(C#C)N(C(C2=CC=CS2)C(NCC(OCC)=O)=O)C1=CC=C(OC)C=C1OC


Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for PACMA 31

溶剂 最高浓度 mg/mL 最高浓度 mM
DMSO 43.05 100

制备储备液 for PACMA 31

以下数据基于产品分子量 430.47。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.32 mL 11.62 mL 23.23 mL
5 mM 0.46 mL 2.32 mL 4.65 mL
10 mM 0.23 mL 1.16 mL 2.32 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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参考文献 for PACMA 31


Ge et al (2013) Small molecule probe suitable for in situ profiling and inhibition of protein disulfide isomerase. ACS.Chem.Biol. 8 2577 PMID: 24070012

Xu et al (2012) Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment. Proc.Natl.Acad.Sci.U.S.A. 109 16348 PMID: 22988091

If you know of a relevant reference for PACMA 31, please let us know.



查看全部 Protein Disulfide Isomerase Inhibitors

关键词: PACMA 31, PACMA 31 supplier, PACMA31, irreversible, protein, disulfide, isomerases, PDI, inhibitors, inhibits, ovarian, cancer, Protein, Disulfide, Isomerase, 5116, Tocris Bioscience

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