主页 / 药理学 / Enzymes / Kinases / PI 3-kinase / PI 3-kinase Inhibitors / Omipalisib

Omipalisib

Cat. No. 6792 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
Cat.No. 6792 - Omipalisib | C25H17F2N5O3S | CAS No. 1086062-66-9
说明： Highly potent PI 3-kinase inhibitor; also potent inhibitor of mTOR and DNA-PK
别名： GSK2126458
化学名： 2,3-Difluoro-N-[2-methoxy-5-[4-(4-pyridazinyl)-6-quinolinyl]-3-pyridinyl]benzenesulfonamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
文献
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性

Highly potent PI 3-K inhibitor (IC50 = 0.04 nM). Also inhibits mTOR (Ki = 0.18 - 0.3 nM) and DNA-PK (IC50 = 0.28 nM). Induces G1 cell cycle arrest and inhibits proliferation of some breast cancer cells lines in vitro. Reduces pAKT-S473 levels in and inhibits growth of BT474 breast cancer xenografts in mice. Orally bioavailable.

技术数据

分子量 505.5
公式 C25H17F2N5O3S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1086062-66-9
PubChem ID 25167777
InChI Key CGBJSGAELGCMKE-UHFFFAOYSA-N
Smiles COC1=NC=C(C2=CC3=C(N=CC=C3C4=CN=NC=C4)C=C2)C=C1NS(=O)(C5=C(C=C(C=C5)F)F)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 10.11 20

制备储备液

以下数据基于产品分子量 505.5。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 9.89 mL 49.46 mL 98.91 mL
1 mM 1.98 mL 9.89 mL 19.78 mL
2 mM 0.99 mL 4.95 mL 9.89 mL
10 mM 0.2 mL 0.99 mL 1.98 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献

参考文献是支持产品生物活性的出版物。

Knight et al (2010) Discovery of GSK2126458, a highly potent inhibitor of PI3K and the mammalian target of rapamycin. ACS Med.Chem.Lett. 1 39 PMID: 24900173

If you know of a relevant reference for Omipalisib, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 PI 3-kinase Inhibitors

关键词: Omipalisib, Omipalisib supplier, PI, 3-Kinase, PI3K, mTOR, DNA-PK, highly, potent, inhibitors, inhibits, orally, bioavailable, anticancer, GSK2126458, DNA-dependent, Protein, Kinase, 6792, Tocris Bioscience

篇 Omipalisib 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 Omipalisib 的引用文献。 您是否知道使用了 Tocris Omipalisib 的优秀论文？ 请告知我们.

Omipalisib 的评论

目前没有该产品的评论。 Be the first to review Omipalisib and earn rewards!

Have you used Omipalisib?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

该领域的文献

Tocris 提供以下领域的科研文献，以展现我们的产品。您不妨现在就索取*或下载所需的文献！

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling