BSJ-03-123 最新

Cat. No. 6921 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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Cat.No. 6921 - BSJ-03-123 | C47H56N10O11 | CAS No. 2361493-16-3

说明： Selective Cdk6 degrader

化学名： N-[2-[2-[2-[2-[4-[6-[(6-Acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]ethoxy]ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性

Selective Cdk6 degrader (DC₅₀ in sub 10 μM range). Displays no degradation of closely related Cdk4.

Negative control BSJ-Bump (Cat. No. 6922) also available.

许可信息

Sold under license from Dana-Farber Cancer Institute

技术数据

分子量	937.02
公式	C₄₇H₅₆N₁₀O₁₁
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	2361493-16-3
PubChem ID	137628658
InChI Key	LUHCYAOYQIFNRN-UHFFFAOYSA-N
Smiles	O=C1N(C2=NC(NC3=CC=C(C=N3)N4CCN(CCOCCOCCOCCNC(COC5=C(C(N(C6C(NC(CC6)=O)=O)C7=O)=O)C7=CC=C5)=O)CC4)=NC=C2C(C)=C1C(C)=O)C8CCCC8

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	93.7	100

制备储备液

以下数据基于产品分子量 937.02。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.07 mL	5.34 mL	10.67 mL
5 mM	0.21 mL	1.07 mL	2.13 mL
10 mM	0.11 mL	0.53 mL	1.07 mL
50 mM	0.02 mL	0.11 mL	0.21 mL

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产品说明书

分析证书/产品说明书

化学品安全技术说明书

参考文献

参考文献是支持产品生物活性的出版物。

Brand et al (2019) Homolog-selective degradation as a strategy to probe the function of CDK6 in AML. Cell Chem.Biol. 26 300 PMID: 30595531

If you know of a relevant reference for BSJ-03-123, please let us know.

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关键词: BSJ-03-123, BSJ-03-123 supplier, cyclin, dependent, kinase, cdk6, degraders, degrades, selective, protac, proteolysis, targeting, chimera, Active, Degraders, Cyclin-dependent, Kinase, 6921, Tocris Bioscience

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Targeted Protein Degradation Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support Targeted Protein Degradation research, including:

Active Degraders (e.g. PROTACs)
Degrader Building Blocks
Custom Degrader Services
UPS Proteins and Assays
Assays for Protein Degradation

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Epigenetics in Cancer Poster

Adapted from the 2015 Cancer Product Guide Edition 3, this poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed.