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ASP 7967

Cat. No. 8803 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Ligand for RNA aptamer AC17-4 activating gene expression in aptazime-based riboswitches
化学名： N2,N4-Bis(4-fluorophenyl)-N6-(2-pyrimidinylmethyl)-1,3,5-triazine-2,4,6-triamine hemifumarate
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ASP 7967

ASP 7967 is a ligand for RNA aptamer AC17-4 that activates gene expression in synthetic aptazime-based riboswitches at as low as 5 μM concentration, without relying on exogenous protein factors. ASP 7967 binds aptamer AC17-4 with high affinity in HEK293 cells (Kd = 12 nM; EC50 = 2.3 μM), activating gene expression (>10-fold) in HEK293 cells. ON/OFF ratio of riboswitches activated by ASP 7967 approaches 300, with a low basal expression level in cultured cells.

In vivo, ASP 7967 upregulates the serum hEPO concentration by 7.2-fold over the vehicle control (mice). Cell permeable and low-toxic, ASP 7967 is orally bioavailable.

技术数据 for ASP 7967

分子量 464.44
公式 C20H16F2N8.½C4H4O4
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1246958-42-8
PubChem ID 46931459
InChI Key PQVNSJGSJVAEAC-WXXKFALUSA-N
Smiles FC1=CC=C(C=C1)NC2=NC(NCC3=NC=CC=N3)=NC(NC4=CC=C(F)C=C4)=N2.OC(/C=C/C(O)=O)=O.FC5=CC=C(C=C5)NC6=NC(NCC7=NC=CC=N7)=NC(NC8=CC=C(F)C=C8)=N6

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ASP 7967

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 46.44 100

制备储备液 for ASP 7967

以下数据基于产品分子量 464.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.77 mL 21.53 mL
5 mM 0.43 mL 2.15 mL 4.31 mL
10 mM 0.22 mL 1.08 mL 2.15 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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参考文献 for ASP 7967

参考文献是支持产品生物活性的出版物。

Salado et al (2018) Optimization of the pharmacokinetic properties of potent anti trypanosomal triazine derivatives. Eur.J.Med.Chem. 151 18 PMID: 29604541

Teixeira et al (2024) Synthetic gene circuits for regulation of next-generation cell-based therapeutics. Adv.Sci. 11 PMID: 38126677

Fukunaga et al (2023) Small-molecule aptamer for regulating RNA functions in mammalian cells and animals. J.Am.Chem.Soc. 145 7820 PMID: 36991533

Takahashi et al (2024) RNA-based controllers for engineering gene and cell therapies. Curr.Opin.Biotech. 85 PMID: 38052131

Olenginski et al (2024) Flipping the script: understanding riboswitches from an alternative perspective. J.Biol.Chem. 300 PMID: 38336293

Kläge et al (2024) A comparative survey of the influence of small self-cleaving ribozymes on gene expression in human cell culture. RNA Biology 21 1 PMID: 38146121

Wang et al (2023) Integrating ligands into nucleic acid systems. ChemBioChem 24 PMID: 37401635

If you know of a relevant reference for ASP 7967, please let us know.

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