New Products

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New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the new products can be identified by this symbol symbol.

If you can't find what you are looking for we welcome new product suggestions. If you would like to be kept informed about new products by email, please sign up for our monthly e-alert service.

7-TM Receptors
Cat.No.
Product Name / Activity
Added
5937A 779

Selective Mas receptor (Ang-(1-7) receptor) antagonist

Jun 2016
5766A 971432

Potent and selective S1P5 agonist

Jun 2016
5940AdTx1

Selective, high affinity, non-competitive α1A adrenoceptor antagonist

Jun 2016
5715(±)-ADX 71743

Negative allosteric modulator at mGlu7; brain penetrant

Sep 2016
5795ATI 2341

CXCR4 allosteric agonist

Apr 2016
5327BGC 20-1531 hydrochloride

High affinity and selective EP4 antagonist

May 2016
5958Desloratadine

High affinity H1 antagonist; anti-inflammatory.

Jul 2016
5858Droperidol

D2 receptor antagonist

Apr 2016
5838[Pro3]-GIP (Mouse)

GIP receptor antagonist

Jun 2016
5837[Pro3]-GIP (Rat)

High affinity rat GIP receptor partial agonist

Jun 2016
5621GLPG 0974

Potent FFA2 antagonist

Jun 2016
5981Itraconazole

SMO antagonist; acts at different binding site to cyclopamine (Cat No. 1623)

Aug 2016
5830K-(D-1-Nal)-FwLL-NH2

High affinity and potent ghrelin receptor inverse agonist

May 2016
5738ML 382

MrgX1 (SNSR4) positive allosteric modulator

May 2016
5904Montelukast sodium

CysLT1 and GPR17 antagonist

May 2016
5954MSG 606

Potent human MC1 receptor antagonist; also MC3 and MC5 partial agonist

Sep 2016
2587Neuropeptide S (human)

Potent endogenous neuropeptide S receptor agonist

Apr 2016
5857Neuropeptide S (Mouse)

Potent endogenous neuropeptide S receptor (NPSR) agonist

May 2016
5859Neuropeptide S (Rat)

Potent endogenous neuropeptide S receptor agonist

Apr 2016
5722Ogerin

Selective positive allosteric modulator at GPR68

Jun 2016
6026Oleanolic acid

Selective GPBA receptor (TGR5) partial agonist

Sep 2016
4862PPTN hydrochloride

High affinity and selective P2Y14 antagonist

Aug 2016
5351PQ 69

Potent and selective A1 antagonist/inverse agonist

Apr 2016
5650SAR 216471 hydrochloride

Potent P2Y12 antagonist; orally available

Jul 2016
5671SB 332235

Potent CXCR2 antagonist

Jun 2016
5719SKF 82958 hydrobromide

D1 agonist

Jul 2016
5039SR 144528

High affinity and selective CB2 inverse agonist

Mar 2016
5902Tiotropium bromide

Potent muscarinic receptor antagonist

May 2016
5693VU 0409551

Selective mGlu5 positive allosteric modulator; brain penetrant and orally bioavailable

Jun 2016
Cell Biology
Cat.No.
Product Name / Activity
Added
5737BAM 15

Mitochondrial protonophore uncoupler

Apr 2016
5590BI 9564

Potent and selective BRD9 and BRD7 inhibitor; orally active

Jun 2016
5901c-Di-AMP sodium salt

Endogenous STING and DDX41 agonist; activates STING-dependent signaling

Apr 2016
5900c-Di-GMP sodium salt

Endogenous STING and DDX41 agonist; activates STING-dependent signaling

Apr 2016
59452',3'-cGAMP sodium salt

Endogenous high affinity STING agonist

Jun 2016
59463',3'-cGAMP sodium salt

STING agonist

Jun 2016
4568CPYPP

DOCK2-Rac1 interaction inhibitor

Mar 2016
5944G10

Activator of STING-dependent signaling

Aug 2016
5655GN 44028

Potent HIF-1α inhibitor

May 2016
57406-Hydroxy-DL-DOPA

Allosteric inhibitor of RAD52; also APE1 inhibitor

Apr 2016
5806ISOX DUAL

Dual BRD4 and CBP/p300 bromodomain inhibitor

May 2016
5808ISOX INACT

Negative control for PF-CBP1 (Cat. No. 5801)

May 2016
5625ML 334

Inhibitor of Keap1- Nrf2 interaction

Jul 2016
5786NI 42

High affinity BRPF inhibitor

Jul 2016
5744NVS-CECR2-1

Potent and selective inhibitor of cat eye syndrome chromosome region, candidate 2 (CECR2)

Aug 2016
5664O4I2

Oct3/4 inducer; induces expression of pluripotent-associated genes

May 2016
5801PF CBP1

Selective CBP/p300 bromodomain inhibitor

Apr 2016
5707RA 839

Nrf2 activator; inhibits Nrf2/Keap1 interaction

Jun 2016
5810RS 1

High affinity RAD51 activator; also CRISPR enhancer

Apr 2016
Compound Libraries
Cat.No.
Product Name / Activity
Added
5840Tocriscreen Plus

A library of 1280 biologically active compounds (250 μL 10mM DMSO solutions)

Jul 2016
5841Tocriscreen Plus Mini

A library of 1280 biologically active compounds (50 μL 10mM DMSO solutions)

Jul 2016
Enzyme-Linked Receptors
Cat.No.
Product Name / Activity
Added
4397AV 412

Potent inhibitor of EGFR, ErbB2 and Abl receptor tyrosine kinases

Aug 2016
5916Canertinib dihydrochloride

Potent EGFR kinase inhibitor

Jun 2016
5800CHMFL-FLT3-122

Potent and selective FLT3 inhibitor

Jun 2016
5870Cilengitide

Potent and selective inhibitor of integrins αvβ3 and αvβ5

Aug 2016
5973CP 724714

Potent and selective ErbB2 inhibitor

Jul 2016
5961HIOC

Selective TrkB receptor agonist; neuroprotectant

Aug 2016
5799Mitoglitazone

Insulin sensitizer; exhibits low binding affinity at PPARγ

Jul 2016
5939PF 6274484

High affinity and potent covalent EGFR kinase inhibitor

Jun 2016
5928RS 09

TLR4 peptide agonist; acts as an adjuvant in vivo

Jun 2016
5445SM 324405

Potent TLR7 agonist

Jun 2016
Enzymes
Cat.No.
Product Name / Activity
Added
5802A37

ALDH1A1 inhibitor

Aug 2016
6006Acein

High affinity angiotensin-converting enzyme (ACE) ligand

Sep 2016
5852Acetyl Pepstatin

High affinity aspartic protease inhibitor; inhibits HIV-1/2 proteinases

Jun 2016
5953Adaptaquin

HIF-prolyl hydroxylase-2 (PHD2) inhibitor; antioxidant

Aug 2016
5773Akti-1/2

Potent and selective dual Akt1 and 2 inhibitor

Jun 2016
5747Apcin

Cdc20 inhibitor; inhibits Cdc20-substrate interaction

Jul 2016
5959Autocamtide-2-related inhibitory peptide, myristoylated

CaM kinase II inhibitor; enhanced cell permeable derivative of Autocamtide-2-related inhibitory peptide

Aug 2016
5775AZ 6102

Potent TNKS1/2 inhibitor

Jun 2016
5796Azoramide

Unfolded protein response (UPR) modulator

Mar 2016
5989BIRB 796

High affinity and selective p38 kinase inhibitor

Jul 2016
5654BMS 265246

Potent cdk1/2 inhibitor

Aug 2016
5301BPTES

Selective allosteric glutaminase (GLS1) inhibitor

Mar 2016
5817BSI 201

PARP-1 inhibitor

May 2016
5836CBR 5884

3-Phosphoglycerate dehydrogenase (PHGDH) inhibitor

Apr 2016
4503CC 0651

Allosteric inhibitor of hCdc34

Jun 2016
4546rac-CCT 250863

Potent Nek2 inhibitor

Sep 2016
5869CDN 1163

SERCA2 allosteric activator

Jun 2016
5774DEL 22379

ERK dimerization inhibitor

Jun 2016
5979Eicosapentaenoic Acid

Endogenous polyunsaturated fatty acid; stimulates ERK1/2 phosphorylation

Aug 2016
5994Enzastaurin

Potent PKCβ inhibitor

Aug 2016
5906Imatinib mesylate

Potent and selective v-Abl tyrosine kinase inhibitor; also inhibits PDGFR and c-kit

May 2016
6007INCB 024360-analog

Potent indoleamine 2,3-dioxygenase (IDO) inhibitor

Aug 2016
5853JNJ DGAT2-A

DGAT2 inhibitor

Apr 2016
5845JX 06

Potent and selective pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor

Apr 2016
5844JZP 430

Potent and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor

Jul 2016
5365LLY 507

Potent SMYD2 inhibitor

Apr 2016
5794LM 10

Selective tryptophan 2,3-dioxygenase (TDO) inhibitor

Jul 2016
5727MC 1742

Potent class I and IIb HDAC inhibitor

Jul 2016
5803MP A08

Selective ATP competitive SphK1 and 2 inhibitor; cell permeable

Jul 2016
5067MRT 68601 hydrochloride

Potent TBK1 inhibitor

Apr 2016
5713MS 023 dihydrochloride

Potent and selective type I PRMT inhibitor

Jul 2016
5681N106

Activator of SUMO-activating enzyme, E1 ligase

Mar 2016
5848NoxA1ds

Potent and selective NADPH oxidase 1 (NOX1) inhibitor

Apr 2016
5651ONO 6818

High affinity and selective human neutraphil elastase 1 (HNE1) inhibitor; orally active

May 2016
5760P-3FAX-Neu5Ac

Sialic acid analog; sialyltransferase inhibitor

May 2016
5930PBIT

JARID1 (Jumonji AT-Rich Interactive Domain 1) inhibitor

Jun 2016
5871pCPA methyl ester hydrochloride

Tryptophan hydroxylase inhibitor

Apr 2016
5166Perhexiline maleate

Carnitine palmitoyltransferase 1 and 2 (CPT1/2) inhibitor

Aug 2016
6004PF 06281355

Selective myeloperoxidase (MPO) inhibitor

Sep 2016
5754PF 543 hydrochloride

Potent and selective SphK1 inhibitor

May 2016
5917PF 9184

Potent microsomal prostaglandin E synthase 1 (mPGES-1) inhibitor

Jul 2016
5866PH 797804

Potent and selective p38α/β inhibitor

Jul 2016
5311RHPS 4 methosulfate

Telomerase inhibitor

Jul 2016
5856Ritonavir

HIV-1 and HIV-2 protease inhibitor

Jun 2016
1332Roscovitine

Potent, selective cyclin-dependent kinase inhibitor

Sep 2016
5714S 2101

LSD1 inhibitor

May 2016
5809SPL 334

S-Nitrosoglutathione reductase inhibitor

Jul 2016
5244TC-E 5008

Selective mutant isocitrate dehydrogenase 1 (mIDH1) inhibitor; phenotypically lethal

Aug 2016
5832TGX 221

Potent and selective PI 3-kinase β inhibitor

May 2016
5960TMI 1

Adam 17 (TACE) and MMP inhibitor; orally bioavailable

Aug 2016
5864Tolcapone

COMT inhibitor; also inhibits transthyretin aggregation

May 2016
5918TPPU

Potent soluble epoxide hydrolase inhibitor; orally bioavailable and brain penetrant

Aug 2016
5907VX 680

High affinity and selective Aurora kinase inhibitor

May 2016
5839XEN 445

Selective endothelial lipase inhibitor; orally bioavailable

May 2016
5667YK 3-237

SIRT1 activator

Jun 2016
Fluorescent Probes
Cat.No.
Product Name / Activity
Added
5935H2DCFDA

Fluorescent ROS indicator; cell permeable

Aug 2016
5905Neurosensor 521

Selective noradrenalin and dopamine fluorescent indicator

Aug 2016
Ion Channels
Cat.No.
Product Name / Activity
Added
5781A 425619

Potent TRPV1 antagonist

Jun 2016
5929BeKm 1

Potent and selective KV11.1 (hERG) channel blocker

Jun 2016
5982cis-6-Hydroxynorketamine hydrochloride

Metabolite of ketamine (Cat.No. 3131); antidepressive

Jul 2016
5807M 084 hydrochloride

TRPC4/5 channel blocker; antidepressant and anxiolytic

Jul 2016
5938Mambalgin 1

Selective ASIC1a inhibitor; analgesic

Jun 2016
5770MONNA

Potent TMEM16A (Anoctamin-1) blocker

Sep 2016
5941OD1

Potent hNav1.4, rNav1.6 and rNav1.7 channel activator

Jun 2016
5018PEAQX tetrasodium salt

Potent NMDA receptor antagonist; NR2A selective

Jul 2016
5931PF 05089771

Potent and selective Nav1.7 channel blocker

Jun 2016
6003PF 05105679

Selective TRPM8 blocker

Sep 2016
5678RN 9893 hydrochloride

Potent and selective TRPV4 antagonist

May 2016
Nuclear Receptors
Cat.No.
Product Name / Activity
Added
5849EC 19

Synthetic retinoid; induces differentiation of stem cells

Sep 2016
5699IP7e

Potent Nurr1 activator

Apr 2016
5964SI-2 hydrochloride

Steroid receptor coactivator 3 (SRC-3) inhibitor

Aug 2016
5868SR 0987

T cell-specific RORγ (RORγt) agonist

Aug 2016
5855SR 9009

Rev-Erbα/β agonist

Jul 2016
5854SR 9238

Potent and selective LXR inverse agonist

May 2016
5951WAY 252623

Potent LXR agonist

Jul 2016
Other Pharmacology
Cat.No.
Product Name / Activity
Added
5811NBD 556

CD4 mimetic; blocks HIV-1 cell entry

Apr 2016
6002Trolox

Antioxidant vitamin E derivative

Jul 2016
Photoswitchable Ligands
Cat.No.
Product Name / Activity
Added
5464AC 4

Photoswitchable TRPV1 channel blocker

Jun 2016
Reagents
Cat.No.
Product Name / Activity
Added
57654-azido-N-ethyl-1,8-naphthalimide

Click-activated fluorescent probe

Mar 2016
5825CHAPSO

Zwitterionic detergent

Apr 2016
Transporters
Cat.No.
Product Name / Activity
Added
5867Ceefourin 1

Selective MRP4 inhibitor

Jul 2016
5725ML 352 hydrochloride

High affinity and selective presynaptic choline transporter (CHT) inhibitor

Apr 2016
5757Tariquidar dihydrochloride

Potent P-glycoprotein (P-gp) inhibitor

Aug 2016

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IVBM 2016

IVBM 2016

October 30 - November 3, 2016

Boston, MA, USA

Booth: 2