New Products

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New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the new products can be identified by this symbol symbol.

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Cat.No.
Product Name / Activity
Added
6165AC 265347

CaSR biased allosteric modulator

Jul 2017
5879ACES

Zwitterionic buffer

Feb 2017
5758AGN 193109

High affinity pan-RAR antagonist

Mar 2017
6161Ailanthone

Potent inhibitor of androgen receptor (AR)

Apr 2017
6034AM 2394

Potent glucokinase activator; orally bioavailable

Jan 2017
6082AMG 837 hemicalcium salt

Potent free fatty acid receptor 1 (FFA1/GPR40) partial agonist

Feb 2017
6086AMP PNP

Kir6 blocker; non-hydrolyzable AMP analog

Mar 2017
5658AR-C 141990 hydrochloride

MCT1 inhibitor

Jul 2017
5720AR-C 69931 tetrasodium salt

Highly potent P2Y12 antagonist

Mar 2017
6219Arformoterol tartrate

Long-acting β2 agonist (LABA)

Apr 2017
5872AZ 10397767

Potent CXCR2 antagonist

Mar 2017
5632AZ Dyrk1B 33

Potent and selective Dyrk1B kinase inhibitor

Jan 2017
5675AZ PFKFB3 26

Potent and selective PFKFB3 inhibitor

May 2017
6085AZD 1283

High affinity P2Y12 antagonist

Jan 2017
6060AZD 2461

Potent PARP inhibitor; orally bioavailable

May 2017
6009B I09

IRE1 endonuclease inhibitor; cell permeable

Apr 2017
5300BI 605906

Selective IKKβ inhibitor

Mar 2017
5881Bicine

General purpose buffer

Feb 2017
6304BigLEN (mouse)

GPR171 agonist

Jul 2017
6306BigLEN (rat)

Potent GPR171 agonist

Jul 2017
5372Bioymifi

DR5 (TRAIL receptor) agonist; induces apoptosis

May 2017
6047BOP

Dual α9β/1α4β1 integrin inhibitor; preferentially mobilizes HSCs

Mar 2017
6232Bosentan

High affinity dual ETA and ETB receptor antagonist;orally bioavailable

Mar 2017
6078BPTU

P2Y1 allosteric antagonist

Jul 2017
6282BRD 4770

G9a inhibitor and S-adenosyl methionine mimetic; cell permeable

Jun 2017
6284BRD 73954

Dual histone deacetylase (HDAC) 6/8 inhibitor

Jun 2017
6264Caerulein

CCK agonist

Mar 2017
5873CAPS

Buffer widely used in Western blotting

Feb 2017
6258CC 401 dihydrochloride

High affinity JNK inhibitor; also inhibits HCMV replication

May 2017
5821C-DIM 12

Nurr1 activator; inhibits NF-κB-dependent gene expression

May 2017
6210ci-IP3/PM

Caged inositol triphosphate

Mar 2017
6170Cinacalcet hydrochloride

Calcium-sensing receptor (CaSR) allosteric agonist; also CYP2D2 inhibitor and Ca2+ channel blocker; orally bioavailable

Feb 2017
6155cis MZ 1

Negative Control for MZ1

Apr 2017
6157cis VH 298

Negative control for VH 298

Apr 2017
5963CMPI hydrochloride

Potent positive allosteric modulator of α4β2 nAChRs; also inhibitor of (α4)2(β2)3, muscle-type and Torpedo nAChRs

May 2017
6117CORM 2

Carbon monoxide-releasing molecule

Jan 2017
6107CP 424174

Inhibitor of IL-1β post-translational processing; indirectly inhibits NLRP3

Mar 2017
5993CP 673451

Potent and selective PDGFR inhibitor

Jan 2017
6174CVT 313

cdk2 inhibitor

Jun 2017
5435Cyanine 3, SE

Orange fluorescent dye for labeling of amines

Mar 2017
5437Cyanine 7, SE

Near-infrared fluorescent dye for labeling of amines

Mar 2017
61378-Cyclopentyl-1,3-dimethylxanthine

High affinity adenosine A1 receptor antagonist

Jan 2017
5921D9

Potent thioredoxin reductase (TrxR) inhibitor

May 2017
6175DBHDA

Reagent for synthetic biology; converts cysteine to dehydroalanine

Apr 2017
6077DETA NONOate

Nitric oxide donor

Jan 2017
62777α,25-Dihydroxycholesterol

Highly potent GPR183 (EBI2) agonist

Jun 2017
5955eCF 309

Potent mTOR inhibitor

Jan 2017
6292ELARR>GG

Negative control for ELA-32 (Cat.No.6291).

Jul 2017
6293ELA-14 (human)

Potent apelin (APJ) receptor agonist

Jun 2017
6294ELA-14 negative control

Negative control for ELA-14 (Cat.No.6293).

Jun 2017
6291ELA-32 (human)

Potent, high affinity apelin receptor agonist; stimulates angiogenesis

Jul 2017
6234Entecavir

Potent and selective hepatitis B virus inhibitor

Apr 2017
6158(S)-Equol

Potent estrogen receptor β (ERβ) agonist

May 2017
62047-Ethoxyresorufin

Fluorometric CYP450 substrate

Mar 2017
6188Everolimus

mTOR inhibitor;immunosuppressant

Apr 2017
5833Ex 26

Potent and selective S1P1 receptor antagonist

Jan 2017
6253F 127 (20% solution in DMSO)

Nonionic detergent

Apr 2017
6100Fasentin

GLUT1/GLUT4 inhibitor; also Fas-sensitizer

May 2017
5911FFN 200 dihydrochloride

Selective fluorescent VMAT2 substrate

Feb 2017
6250Filipin III

Polyene antibiotic; inhibits formation of pathological isoform of prion protein

Mar 2017
6029FRAX 597

Potent group I PAK inhibitor

Feb 2017
6176FTY 720

Potent S1P receptor agonist; also immunosuppressant

Feb 2017
5407GA3-AM

Gibberellin-analog (GA3) chemical dimerizer; cell permeable

Mar 2017
6108Galeterone

CYP17 inhibitor; also androgen receptor antagonist

Jan 2017
6218Galiellalactone

STAT3 inhibitor; active in vivo

Apr 2017
6056GSK 1363089

Potent inhibitor of MET, VEGFR2, Ron and AXL

Jan 2017
5672GSK 319347A

Potent and selective IKKε inhibitor

Feb 2017
6128GSK 343

Potent and selective SAM-competitive EZH2 inhibitor

Jun 2017
5777GSK 591 dihydrochloride

Potent and selective PRMT5 inhibitor

Feb 2017
6211H3K27(Me) (15-34)

Histone H3 peptide; substrate for demethylase/methyltransferase enzymes

Apr 2017
6212H3K27(Me2) (15-34)

Histone H3 peptide; substrate for methyltransferase/demethylase enzymes

Apr 2017
6213H3K27(Me3) (15-34)

Histone H3 peptide; substrate for methyltransferase/demethylase enzymes

Apr 2017
6214H3K4(Me) (1-20)

Histone H3 peptide; substrate for methyltransferase/demethylase enzymes

Apr 2017
6215H3K4(Me2) (1-20)

Histone H3 peptide

May 2017
6216H3K4(Me3) (1-20)

Histone H3 peptide; substrate for methyltransferase/demethylase enzymes

Apr 2017
6217Histone H3 (1-34)

Histone H3 peptide

Apr 2017
5850HM 50316

High affinity FABP4 inhibitor

Feb 2017
5768HS 38

ATP-competitive inhibitor of DAPK and ZIPK

Jul 2017
574125-Hydroxycholesterol

Antiviral; also α-crystallin (cryAB) chaperone

Apr 2017
6124(R)-2-Hydroxyglutaric acid disodium salt

KDM4A inhibitor; also NF-κB activator

Jan 2017
6016IN 1130

Potent and selective inhibitor of TGF-βRI

Jul 2017
5846IT 901

NF-κB c-Rel subunit inhibitor

Feb 2017
5692ITH 12575

Mitochondrial Na+/Ca2+ exchange (mNCX) inhibitor.

Jan 2017
6147Janelia Fluor® 549, SE

Cell permeable fluorescent dye; supplied as NHS ester

Feb 2017
6148Janelia Fluor® 646, SE

Cell permeable fluorescent dye; supplied as NHS ester

Feb 2017
4322JH 295

Irreversible Nek2 inhibitor

May 2017
5865KLH 45

Potent DDHD2 inhibitor

Mar 2017
6146LAP

Photocrosslinker for hydrogels

Mar 2017
3974Latrunculin B

Inhibitor of actin polymerization

May 2017
6151LDN 212854

Potent bone morphogenetic protein type I (ALK) inhibitor

Apr 2017
6152LDN 214117

Potent and selective ALK2 inhibitor

Apr 2017
5826LEI 101 hydrochloride

Potent and selective CB2 partial agonist; orally biovailable

May 2017
6305Lenalidomide

Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase

Jun 2017
5103Lys-CoA

Selective p300 inhibitor

Jun 2017
5785MDNI-caged-L-glutamate

Stable photoreleaser of L-glutamate

Feb 2017
6285Megestrol Acetate

Synthetic progesterone analog

May 2017
5842MK 386

Potent, selective human type 1 5α-reductase inhibitor

May 2017
5987(±)-ML 209

RORγt inverse agonist; suppresses Th17 cell differentiation

Apr 2017
5700ML 315 hydrochloride

Inhibitor of Clk and DYRK kinases

Apr 2017
5943ML 339

Potent and selective hCXCR6 antagonist

Feb 2017
6171MLS 1547

G protein-biased D2 receptor partial agonist

Mar 2017
6131(R)-Modafinil

Dopamine uptake inhibitor

Jan 2017
5888MOPSO, free acid

Buffer; working pH range in aqueous solution: 6.2-7.6

May 2017
5780MRT 68921 dihydrochloride

Potent ULK inhibitor; inhibits autophagy

Feb 2017
6208MS 275

HDAC (Class I) inhibitor

Jun 2017
6189Myricetin

Irreversible TrxR inhibitor

Jun 2017
6154MZ 1

(+)-JQ1 based PROTAC that selectively degrades BRD4 in cells.

Apr 2017
6183Nanchangmycin

Antiviral; active against Zika, West Nile and dengue viruses

May 2017
5986NAV 2729

Selective ARF6 inhibitor

Feb 2017
6121NB-caged Tyrosine hydrochloride

ortho-nitrobenzyl caged L- tyrosine

May 2017
5150NCL 00017509

Potent and reversible NIMA related kinase 2 (Nek2) inhibitor

May 2017
5934NCT 501 hydrochloride

Potent and selective ALDH1A1 inhibitor

Jan 2017
5976Ned K

NAADP signaling inhibitor

Apr 2017
6045NITD 008

Antiviral; selective flavivirus inhibitor

Jul 2017
6180NMS 873

Potent and selective p97 ATPase (VCP) allosteric inhibitor

Apr 2017
6181OTX 015

BET bromodomain inhibitor; orally bioavailable

May 2017
6012OXSI 2

Potent Syk kinase inhibitor; also inhibits assembly of NLRP3 inflammasomes

May 2017
6073P21d hydrochloride

Potent and selective Brk inhibitor

Jun 2017
6149PA Janelia Fluor® 549, SE

Photoactivatable cell permeable fluorescent dye; supplied as NHS ester

Apr 2017
6150PA Janelia Fluor® 646, SE

Photoactivatable cell permeable fluorescent dye; supplied as NHS ester

Apr 2017
6303Parathyroid hormone (1-34) (bovine)

Parathyroid hormone (PTH) receptor agonist.

Jun 2017
6301Parathyroid hormone (1-34) (rat)

Parathyroid hormone (PTH) receptor agonist

Jun 2017
5419PCNA I1

PCNA inhibitor

Feb 2017
6185Pemetrexed

High affinity dihydrofolate reductase inhibitor; also inhibits thymidylate synthase, GARFT and AICART

Jun 2017
6288Peptide YY (3-36) human

NPY Y2 receptor agonist

Jun 2017
6169PF 06726304 acetate

Highly potent and SAM-competitive EZH2 inhibitor

Feb 2017
6005PF 3758309 dihydrochloride

Potent PAK4 inhibitor; orally available

Jan 2017
6221PKI (5-24)

High affinity PKA inhibitor

Mar 2017
6302Pomalidomide

Cereblon ubiquitination inhibitor; also TNFα inhibitor and antiangiogenic

Jun 2017
6317Prasugrel

Irreversible P2Y12 antagonist; antiplatelet and orally active

Jul 2017
6259RAGE antagonist peptide

Receptor for advanced glycation end products (RAGE) antagonist

May 2017
6233Retigabine

KV7 channel activator

Mar 2017
6190Retrobradykinin

Reverse analog of Bradykinin

Apr 2017
6168RI 1

RAD51 recombinase inhibitor

Apr 2017
6088SB 3CT

Selective high affinity MMP2 inhibitor

Feb 2017
6164SEA 0400

Potent Na+/Ca2+ exchanger (NCX) inhibitor.

Apr 2017
6101SHIP 2a

Cystathione γ lyase (CSE) inhibitor

Feb 2017
5452SKI 178

Non-lipid sphingosine kinase 1 (SphK1) inhibitor

May 2017
6138SR 9243

Selective LXR inverse agonist

Mar 2017
6271ST 034307

Adenylyl cyclase 1 (AC1) inhibitor; analgesic and active in vivo

May 2017
6286st-Ht31

Inhibits PKA/AKAP interactions; cell permeable

Jul 2017
6287st-Ht31 P

Negative control for st-Ht31 (Cat. No. 6286)

Jul 2017
6036STK16-IN-1

Serine/threonine protein kinase 16 (STK16) inhibitor; also inhibits PI 3Kδ, PI 3Kγ and mTOR kinases.

May 2017
6311Tadalafil

Potent and highly selective PDE5 inhibitor; orally bioavailable

May 2017
5729TASP 0390325

Potent and selective V1B receptor antagonist; orally bioavailable

Apr 2017
5362TASP 0433864

Selective mGlu2 receptor positive allosteric modulator

Feb 2017
6227TAT-Gap19

Cx43 hemichannel blocker

Apr 2017
6105TC AC 28

High affinity BET bromodomain ligand

Mar 2017
6092TDZD 8

Selective non-ATP competitive inhibitor of GSK 3β

Mar 2017
61594,9-Anhydrotetrodotoxin

Potent and selective Nav1.6 channel blocker

Jan 2017
6191TH 1020

Toll-like receptor (TLR) 5/Flagellin complex antagonist

Jul 2017
6194TM 5441

Plasminogen activator inhibitor-1 (PAI-1) inhibitor

Jun 2017
5933Tocriscreen Kinase Inhibitor Toolbox I

A library of 80 kinase inhibitor compounds (250 μL 10 mM DMSO solutions)

Apr 2017
6268Tocriscreen Kinase Inhibitor Toolbox I & II

A library of 160 kinase inhibitor compounds (250 μL 10 mM DMSO solutions)

Apr 2017
6225Tocriscreen Kinase Inhibitor Toolbox II

A library of 80 kinase inhibitor compounds (250 μL 10 mM DMSO solutions)

Apr 2017
5932Tocriscreen Library of FDA-Approved Compounds

A library of 160 FDA-approved compounds (250 μL 10 mM DMSO solutions)

Mar 2017
6008TP 064

Potent and selective PRMT 4 inhibitor

Jan 2017
5999TP 472N

Negative control for TP 472 (Cat. No. 6000).

Jan 2017
5343TPPB

High affinity PKC activator; also APP modulator

May 2017
6270Tubastatin A hydrochloride

Potent HDAC6 inhibitor

Jun 2017
5518UMB 68

GHB receptor ligand

Jan 2017
4930UNC 2399

Biotinylated UNC 1999 (Cat.No. 4904)

Jun 2017
6156VH 298

High-affinity inhibitor of VHL

Apr 2017
6202Vilazodone hydrochloride

Potent 5-HT1A partial agonist and SSRI; antidepressant

Apr 2017
6061XMD 8-87

Potent Ack1/TNK2 inhibitor

May 2017
6111Zoledronic Acid

Potent farnesyl diphosphate (FPP) synthase inhibitor

Feb 2017

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New Product Guide

Spring/Summer 2017

New Product Guide (Spring/Summer 2017)

Our New Product guide highlights over 130 new products added in the first half of 2017. View PDF today.

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