New Products

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New products are an essential component of our range. Introductions are made on an ongoing basis, with hundreds of new small molecules and peptides being added every year. Our aim is to find the latest, otherwise unobtainable research tools, and bring them to the market as quickly as we can. New products can be identified throughout the Tocris website by the new products can be identified by this symbol symbol.

If you can't find what you are looking for we welcome new product suggestions. If you would like to be kept informed about new products by email, please sign up for our monthly e-alert service.

Cat.No.
Product Name / Activity
Added
5879ACES

Zwitterionic buffer

Feb 2017
5758AGN 193109

High affinity pan-RAR antagonist

Mar 2017
6034AM 2394

Potent glucokinase activator; orally bioavailable

Jan 2017
5789AM 4668

Potent FFA1 (GPR40) agonist

Oct 2016
6043AMBMP hydrochloride

Wnt canonical signaling activator; also tubulin polymerization inhibitor

Nov 2016
5995AMG 517

Potent TRPV1 antagonist

Oct 2016
6082AMG 837 hemicalcium salt

Potent free fatty acid receptor 1 (FFA1/GPR40) partial agonist

Feb 2017
5701AMG 853

Potent dual CRTH2 and prostaglandin D2 (PGD2) receptor antagonist

Oct 2016
6086AMP PNP

Kir6 blocker; non-hydrolyzable AMP analog

Mar 2017
6030Amylin (rat)

Potent endogenous peptide agonist for amylin, calcitonin, CGRP and adrenomedullin receptors

Dec 2016
6076Ani 9

Potent and selective TMEM16A (Anoctamin-1; ANO1) blocker

Dec 2016
59623-AP

Ribonucleotide reductase inhibitor; also an iron chelator

Nov 2016
5720AR-C 69931 tetrasodium salt

Highly potent P2Y12 antagonist

Mar 2017
6058ATN 161

α5β1 integrin receptor antagonist

Nov 2016
5843AX 15836

Potent and selective ERK5 inhibitor

Nov 2016
5872AZ 10397767

Potent CXCR2 antagonist

Mar 2017
5632AZ Dyrk1B 33

Potent and selective Dyrk1B kinase inhibitor

Jan 2017
5742AZ PFKFB3 67

Potent and selective PFKFB3 inhibitor

Oct 2016
6085AZD 1283

High affinity P2Y12 antagonist

Jan 2017
5970BAY 299

Potent and selective BRD1 and TAF1 inhibitor

Dec 2016
5708BAY 41-8543

Guanylyl cyclase (sGC) stimulator

Oct 2016
6052BAY 58-2667 hydrochloride

Potent soluble guanylyl cyclase (sGC) activator

Dec 2016
5300BI 605906

Selective IKKβ inhibitor

Mar 2017
5881Bicine

General purpose buffer

Feb 2017
5908Bis-ANS

Fluorescent probe for nonpolar cavities in proteins; used to detect Aβ fibres

Nov 2016
5488BML 111

FPR2 (lipoxin A4 receptor) agonist

Dec 2016
5762BMS 795311

Potent cholesteryl ester transfer protein (CETP) inhibitor

Oct 2016
5983BMS 986187

Potent δ-opioid receptor positive allosteric modulator

Oct 2016
6047BOP

Dual α9β/1α4β1 integrin inhibitor; preferentially mobilizes HSCs

Mar 2017
6232Bosentan

High affinity dual ETA and ETB receptor antagonist;orally bioavailable

Mar 2017
5312BRACO 19 trihydrochloride

Telomerase inhibitor

Dec 2016
6010BRD 4354

HDAC5 and HDAC9 inhibitor

Oct 2016
5791Bz 423

ATP synthase inhibitor; proapoptotic

Nov 2016
6031Calcitonin (human)

Endogenous calcitonin receptor agonist; inhibits bone resorption

Dec 2016
5873CAPS

Buffer widely used in Western blotting

Feb 2017
6063CCF 642

Protein disulfide isomerase (PDI) inhibitor

Jan 2017
5804Chaetoglobosin A

Antibiotic; selective apoptosis inducer of CLL cells

Nov 2016
6210ci-IP3/PM

Caged inositol triphosphate

Mar 2017
6170Cinacalcet hydrochloride

Calcium-sensing receptor (CaSR) allosteric agonist; also CYP2D2 inhibitor and Ca2+ channel blocker; orally bioavailable

Feb 2017
5125CKD 602

Topoisomerase I inhibitor

Dec 2016
6117CORM 2

Carbon monoxide-releasing molecule

Jan 2017
6107CP 424174

Inhibitor of IL-1β post-translational processing; indirectly inhibits NLRP3

Mar 2017
5993CP 673451

Potent and selective PDGFR inhibitor

Jan 2017
6025(S)-Crizotinib

MTH1 inhibitor

Oct 2016
5436Cyanine 5, SE

Red fluorescent dye for the labeling of amines

Nov 2016
61378-Cyclopentyl-1,3-dimethylxanthine

High affinity adenosine A1 receptor antagonist

Jan 2017
6071CZC 25146

Potent LRRK2 inhibitor

Dec 2016
6077DETA NONOate

Nitric oxide donor

Jan 2017
6019Diprotin A

Dipeptidyl peptidase IV (DPP-IV) inhibitor

Nov 2016
5955eCF 309

Potent mTOR inhibitor

Jan 2017
5695Eggmanone

Potent and selective PDE4 inhibitor; suppresses hedgehog signaling

Oct 2016
62047-Ethoxyresorufin

Fluorometric CYP450 substrate

Mar 2017
5833Ex 26

Potent and selective S1P1 receptor antagonist

Jan 2017
5911FFN 200 dihydrochloride

Selective fluorescent VMAT2 substrate

Feb 2017
6250Filipin III

Polyene antibiotic; inhibits formation of pathological isoform of prion protein

Mar 2017
6029FRAX 597

Potent group I PAK inhibitor

Feb 2017
6011FSL 1

TLR2/6 agonist (also a putative TLR10 ligand)

Nov 2016
6176FTY 720

Potent S1P receptor agonist; also immunosuppresent

Feb 2017
5407GA3-AM

Gibberellin-analog (GA3) chemical dimerizer; cell permeable

Mar 2017
6108Galeterone

CYP17 inhibitor; also androgen receptor antagonist

Jan 2017
6056GSK 1363089

Potent inhibitor of MET, VEGFR2, Ron and AXL

Jan 2017
5672GSK 319347A

Potent and selective IKKε inhibitor

Feb 2017
5777GSK 591 dihydrochloride

Potent and selective PRMT5 inhibitor

Feb 2017
4991HaXS8

Chemical dimerizer

Jan 2017
5850HM 50316

High affinity FABP4 inhibitor

Feb 2017
5824Hoechst 33258

Fluorescent dye for labeling DNA

Nov 2016
6124(R)-2-Hydroxyglutaric acid disodium salt

KDM4A inhibitor; also NF-κB activator

Jan 2017
60942R,6R-Hydroxynorketamine hydrochloride

Enhances AMPA currents; decreases D-serine (a NMDA co-agonist); lacks ketamine-related side effects

Jan 2017
60952S,6S-Hydroxynorketamine hydrochloride

Decreases D-serine (a NMDA co-agonist); antidepressant

Jan 2017
5561IHR-Cy3

Potent fluorescent Smo antagonist

Nov 2016
5965ISAM 140

High affinity A2B receptor antagonist

Oct 2016
5846IT 901

NF-κB c-Rel subunit inhibitor

Feb 2017
5692ITH 12575

Mitochondrial Na+/Ca2+ exchange (mNCX) inhibitor.

Jan 2017
6147Janelia Fluor™ 549, SE

Cell permeable fluorescent dye; supplied as NHS ester

Feb 2017
6148Janelia Fluor™ 646, SE

Cell permeable fluorescent dye; supplied as NHS ester

Feb 2017
5851JZP 361

Potent and selective reversible MAGL inhibitor

Nov 2016
6146LAP

Photocrosslinker for hydrogels

Mar 2017
6053LDN 193189 dihydrochloride

Potent and selective ALK2 and ALK3 inhibitor; promotes neural induction of hPSCs

Nov 2016
6068Lin28 1632

RNA binding protein Lin28 inhibitor; promotes mESC differentiation; also bromodomain inhibitor

Nov 2016
5834LTURM 34

Potent DNA-PK inhibitor

Nov 2016
5835LTURM 36

PI 3-kinase δ inhibitor

Nov 2016
5785MDNI-caged-L-glutamate

Stable photoreleaser of L-glutamate

Feb 2017
6033(R)-MG 132

Potent 20S proteasome inhibitor

Nov 2016
5966ML 233

Non-peptide apelin receptor agonist

Jan 2017
5943ML 339

Potent and selective hCXCR6 antagonist

Feb 2017
5756MLi-2

Potent and selective LRRK2 inhibitor

Nov 2016
6171MLS 1547

G protein-biased D2 receptor partial agonist

Mar 2017
5992MM 54

Potent apelin receptor antagonist

Nov 2016
6131(R)-Modafinil

Dopamine uptake inhibitor

Jan 2017
5780MRT 68921 dihydrochloride

Potent ULK inhibitor; inhibits autophagy

Feb 2017
6046Naloxone fluorescein acetate

Fluorescent opioid antagonist; fluorescent-derivative of naloxone (Cat. No. 0599)

Nov 2016
5986NAV 2729

Selective ARF6 inhibitor

Feb 2017
60652-NBDG

Fluorescent glucose uptake indicator

Nov 2016
5934NCT 501 hydrochloride

Potent and selective ALDH1A1 inhibitor

Jan 2017
5996(R)-Norketamine hydrochloride

NMDA receptor modulator; analgesic

Jan 2017
6112(S)-Norketamine hydrochloride

NMDA receptor modulator; analgesic

Jan 2017
5724NQ 301

Selective CD45 inhibitor

Nov 2016
5779NSC 23005 sodium

Potently promotes HSC expansion ; p18INK inhibitor

Nov 2016
5813NSC 668036

Wnt signaling inhibitor; binds the PDZ domain of the Dishevelled (Dvl) protein

Dec 2016
6066OAC-2

Oct4 activator; enhances iPSC reprogramming efficiency

Dec 2016
4447Org 24598

Inhibitor of GlyT1; derivative of Org 24598 (Cat. No. 4035).

Nov 2016
6014Org 48762-0

Selective p38α/β inhibitor; orally bioavailable

Jan 2017
5419PCNA I1

PCNA inhibitor

Feb 2017
5952PDD 00017273

Potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor; cell permeable

Nov 2016
6087Perifosine

PKB/Akt inhibitor; also modulates Kv2.1 current

Dec 2016
5915PF 04449613

Potent PDE9 inhibitor; brain penetrant

Nov 2016
6115PF 06273340

Potent and selective pan-Trk inhibitor; peripherally restricted

Jan 2017
6114PF 06409577

Potent and selective allosteric activator of AMPK

Jan 2017
6169PF 06726304 acetate

Highly potent and SAM-competitive EZH2 inhibitor

Feb 2017
6005PF 3758309 dihydrochloride

Potent PAK4 inhibitor; orally available

Jan 2017
5919PI 3065

Potent and selective PI 3-kinase p110δ inhibitor

Oct 2016
6070Pladienolide B

mRNA splicing inhibitor; antitumor

Nov 2016
6015RAF 265

Raf kinase and VEGFR-2 inhibitor

Dec 2016
6233Retigabine

KV7 channel activator

Mar 2017
5761RG 102240

Gene switch ligand for use in induceable gene expression systems

Oct 2016
5909RMM 46

MSK/RSK family kinase inhibitor

Nov 2016
5968Ro 3280

Potent and selective PLK1 inhibitor

Dec 2016
5913Ro 6842262

Potent LPA1 antagonist

Nov 2016
5282SAG 21k

Hedgehog signaling activator; brain penetrant and orally bioavailable

Nov 2016
6088SB 3CT

Selective high affinity MMP2 inhibitor

Feb 2017
6101SHIP 2a

Cystathione γ lyase (CSE) inhibitor

Feb 2017
6090Spexin

Potent GAL2/3 agonist; exhibits anxiolytic effects in vivo

Nov 2016
6138SR 9243

Selective LXR inverse agonist

Mar 2017
5570STOCK2S 26016

Lysine deficient protein kinase (WNK) signaling inhibitor

Oct 2016
5362TASP 0433864

Selective mGlu2 receptor positive allosteric modulator

Feb 2017
6092TDZD 8

Selective non-ATP competitive inhibitor of GSK 3β

Mar 2017
61594,9-Anhydrotetrodotoxin

Potent and selective Nav1.6 channel blocker

Jan 2017
5932Tocriscreen Library of FDA-Approved Compounds

A library of 160 FDA-approved compounds (250 μL 10 mM DMSO solutions)

Mar 2017
6008TP 064

Potent and selective PRMT 4 inhibitor

Jan 2017
6000TP 472

Potent BRD9/7 inhibitor

Dec 2016
5999TP 472N

Negative control for TP 472 (Cat. No. 6000).

Jan 2017
5518UMB 68

GHB receptor ligand

Jan 2017
6020URB 602

Non-competitive MAGL inhibitor

Oct 2016
5978WL 47 - dimer

High affinity caveolin-1 ligand

Jan 2017
6111Zoledronic Acid

Potent farnesyl diphosphate (FPP) synthase inhibitor

Feb 2017
6001ZQ 16

Selective GPR84 agonist

Nov 2016

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New Product Guide

New Product Guide (Fall/Winter 2016)

Our New Product guide highlights over 100 new products added in the second half of 2016. Request copy or view PDF today.

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Bio-Techne Events

BNA festival

BNA 2017 Festival of Neuroscience

April 10 - 13, 2017

Birmingham, UK

Booth: 40