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Displaying products alphabetically by name (I)

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Cat.No.
Product Name / Activity
2469IBC 293

Selective agonist for the GPR109B (HM74) receptor. Antilipolytic

1086Iberiotoxin

KCa channel blocker (big conductance)

4650I-BET 151 dihydrochloride

BET bromodomain inhibitor; also promotes differentiation of hiPSCs into megakaryocytes

1066IB-MECA

A3 selective agonist

2845IBMX

PDE inhibitor (non-selective)

0285Ibotenic acid

Non-selective NMDA agonist

07484-IBP

σ ligand, σ1 > σ2

5591I-BRD9

Potent and selective BRD9 inhibitor

1694Ibudilast

PDE inhibitor (non-selective)

2796(S)-(+)-Ibuprofen

Cyclooxygenase inhibitor (COX-1 > COX-2)

3908Ibutilide hemifumarate

Blocks IKr, hERG and L-type Ca2+ channels; class III antiarrhythmic

4305ICA 069673

KV7.2/KV7.3 channel opener

4950ICA 110381

KV7.2/7.3 activator; displays anticonvulsant properties

5066ICA 121431

Potent and selective NaV1.3 and NaV1.1 channel blocker

4891I-CBP 112

Selective CBP/p300 BRD inhibitor

4505ICG 001

Inhibits TCF/β-catenin-mediated transcription

0821ICI 118,551 hydrochloride

Very selective β2 antagonist

0827ICI 154,129

δ selective peptide antagonist

0833ICI 162,846

Potent H2 antagonist, active in vivo

0820ICI 174,864

δ selective peptide antagonist

1047ICI 182,780

Estrogen receptor antagonist

0836ICI 185,282

Potent thromboxane receptor antagonist

0837ICI 192,605

Potent thromboxane A2/TP receptor antagonist

0778ICI 199,441 hydrochloride

Potent κ agonist

0822ICI 204,448 hydrochloride

κ agonist, acts peripherally

0929ICI 215,001 hydrochloride

β3 agonist

1816ICI 63197

PDE4 inhibitor

0832ICI 89406

β antagonist

1531Icilin

Activates a novel cold receptor. Cooling agent

4299iCRT 14

Inhibits β-catenin-responsive transcription (CRT)

3853ID 8

Sustains self-renewal and pluripotency of ESCs

0793Idazoxan hydrochloride

α2 antagonist. Also I2 ligand

4015IDE 1

Induces definitive endoderm formation in mouse and human ESCs

4016IDE 2

Induces definitive endoderm formation in mouse and human ESCs

3002Idebenone

Antioxidant and neuroprotective agent

1219IDRA 21

Inhibits AMPA receptor desensitization

1636IEM 1460

Open-channel blocker of AMPA currents; selective for non-GluR2-containing receptors

4199IEM 1754 dihydrobromide

Voltage-dependent, open-channel blocker of AMPA currents

4198IEM 1925 dihydrobromide

Voltage- and use-dependent open-channel antagonist of AMPA receptors

1576Ac-IEPD-AFC

Fluorogenic granzyme B substrate

0545Ifenprodil hemitartrate

Non-competitive NMDA antagonist. Also σ ligand

2892threo Ifenprodil hemitartrate

NR2B-selective NMDA antagonist; also σ agonist

2332(+)-Igmesine hydrochloride

Selective σ1 ligand; antidepressant

5554IHR 1

Potent Smo antagonist

2539IKK 16

Selective inhibitor of IKK

2038Iloprost

Prostacyclin (PGI2) analog

3794iMAC2

Suppressor of mitochondrial apoptosis

5906Imatinib mesylate

Potent and selective v-Abl tyrosine kinase inhibitor; also inhibits PDGFR and c-kit

2611IMD 0354

Inhibitor of IKKβ

5126iMDK

Suppressor of MDK expression; inhibits PI 3-K signaling

0729Imetit dihydrobromide

Standard H3 and H4 agonist (H3 > H4)

0986Imiloxan hydrochloride

Highly selective α2B antagonist

09512-Iminopiperidine hydrochloride

Selective iNOS inhibitor

3700Imiquimod

Toll-like receptor 7 (TLR7) agonist

0932Immepip dihydrobromide

Standard H3 agonist. Also H4 agonist

2315Immethridine dihydrobromide

Potent H3 agonist, highly selective over H4

1858Impentamine dihydrobromide

Selective H3 antagonist

2162INCA-6

Inhibitor of calcineurin-substrate association

6007INCB 024360-analog

Potent indoleamine 2,3-dioxygenase (IDO) inhibitor

4306INCB 3284 dimesylate

Selective CCR2 antagonist

1588Indatraline hydrochloride

Potent 5-HT uptake inhibitor; also inhibits dopamine and noradrenalin uptake

3728Indibulin

Microtubule destabilizer

3597Indiplon

Subtype-selective GABAA receptor positive allosteric modulator

1813Indirubin-3'-oxime

GSK-3β inhibitor. Also inhibits other protein kinases

1708Indomethacin

Cyclooxygenase inhibitor (COX-1 > COX-2)

4997INDY

DYRK1A/B inhibitor

3551INH1

Hec1 inhibitor; causes arrest of mitosis

1420D-myo-Inositol-1,3,4,5-tetrakisphosphate, octapotassium salt

Potent inhibitor of Ins(1,4,5)P3 5-phosphatase. Metabolite of Cat. No. 1482

1482D-myo-Inositol 1,4,5-trisphosphate, hexapotassium salt

Ca2+ mobilizing second messenger

3435Insulin (human) recombinant
expressed in yeast

Endogenous peptide agonist

15185-Iodo-A-85380 dihydrochloride

High affinity α4β2 and α6β2 subtype-selective agonist

15275-Iodo-A-85380, 5-trimethylstannyl N-BOC derivative

Precursor to 5-Iodo-A-85380 (Cat. No. 1518)

07372-Iodomelatonin

High affinity melatonin agonist

19756-Iodonordihydrocapsaicin

Potent, competitive vanilloid receptor antagonist

0779Iodophenpropit dihydrobromide

Potent, selective H3 antagonist

13625'-Iodoresiniferatoxin

Potent, silent TRPV1 antagonist

15566'-Iodoresiniferatoxin

High affinity TRPV1 agonist/partial agonist

17455-Iodotubercidin

Potent adenosine kinase inhibitor; also inhibits nucleoside transporters and a range of other kinases

0307(S)-(-)-5-Iodowillardiine

Highly potent, subtype-selective kainate agonist

1704Ionomycin calcium salt

Calcium ionophore

2092Ionomycin free acid

Calcium ionophore

4464IOX 1

Histone demethylase inhibitor; cell permeable

4451IOX 2

Potent, selective HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor

5699IP7e

Potent Nurr1 activator

3622IPA 3

Group I PAK inhibitor

0544IPAG

Potent σ antagonist

34294-IPP

Inhibitor of macrophage migration inhibitory factor (MIF); suicide substrate

0692Ipratropium bromide

Muscarinic antagonist

1869Ipsapirone

Selective 5-HT1A agonist

5645IPSU

OX2 receptor antagonist; orally bioavailable

5509IPTG

Used in cloning procedures with X-GAL

4713IQ 1

Enables Wnt/β-catenin-driven expansion of ESCs; prevents spontaneous differentiation

5575IQ 1S

JNK inhibitor; anti-inflammatory; also NO donor

4550IQ 3

Selective JNK3 inhibitor

5665IRAK1/4 Inhibitor I

IRAK4 and IRAK1 inhibitor

5798Irbesartan

Potent AT1 antagonist

3000Iressa

Orally active, selective EGFR inhibitor

1838IRL-2500

Potent ETB antagonist

1195IRL-1038

ETB antagonist

1196IRL-1620

Highly selective ETB agonist

2504Irsogladine maleate

PDE4 inhibitor; antiulcer agent

0992Isamoltane hemifumarate

5-HT1B antagonist

4695Ischemin sodium salt

CBP inhibitor; cell permeable

4288ISO 1

Macrophage migration inhibitory factor (MIF) inhibitor

0235Isoguvacine hydrochloride

Selective GABAA agonist

0897S-Isopropylisothiourea hydrobromide

iNOS inhibitor, acts at arginine binding site

1747Isoproterenol hydrochloride

Standard selective β agonist

5513Isotretinoin

Endogenous agonist for retinoic acid receptors; inducer of neuronal differentiation

5806ISOX DUAL

Dual BRD4 and CBP/p300 bromodomain inhibitor

5808ISOX INACT

Negative control for PF-CBP1 (Cat. No. 5801)

5408Ispinesib

High affinity and selective allosteric KSP inhibitor

2004Isradipine

Ca2+ channel blocker (L-type)

5284trans-ISRIB

Integrated stress response (ISR) inhibitor

5147Istradefylline

Potent and selective adenosine A2A receptor antagonist

4439ISX 9

Neurogenic agent; induces neuronal differentiation of SVZ progenitors and also induces cardiomyogenic differentiation

4596IT1t dihydrochloride

Potent CXCR4 antagonist

5068ITD 1

Selective inhibitor of TGF-β signaling; induces cardiomyocyte differentiation in ESCs

1803ITE

Endogenous agonist for the transcription factor aryl hydrocarbon receptor

5981Itraconazole

SMO antagonist; acts at different binding site to cyclopamine (Cat No. 1623)

3792ITX 3

Selective inhibitor of TrioN RhoGEF activity

4088IU1

USP14 inhibitor

1260Ivermectin

Allosteric modulator of α7 nicotinic receptors

5156Ivermectin B1a-d2

Deuterated ivermectin B1a (Cat. No. 1260)

5279IWP 12

Potent PORCN inhibitor; active in vivo

3533IWP 2

PORCN inhibitor; inhibits Wnt processing and secretion

5214IWP 4

Potent inhibitor of Wnt/β-catenin signaling

4992IWP L6

Potent PORCN inhibitor

3532endo-IWR 1

Wnt/β-catenin signaling inhibitor; axin stabilizer

3947exo-IWR 1

Negative control for endo-IWR 1 (Cat. No. 3532)

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