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Cellular Processes
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Product Type
All Products
New Products
Small Molecules
Peptides
Controlled Substances
Toxins
Caged Compounds
Fluorescent Probes
Screening Libraries
Ligand Sets
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Research Area
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
Properties of Voltage-Gated Sodium Channels
| Location | Subtype | TTX Sensitive? | Conductance (pS) |
|---|
| Brain | I, II, IIA, III, VI | Yes | 2.5-25 |
| Skeletal muscle | μ1 | Yes | 2.5-25 |
| Sympathetic ganglia | PN1 | Yes | 6.3-10.7 |
| Heart | h1 | No (IC50 6 μM) | 2.5-25 |
| Dorsal root ganglia | PN3/SNS | No (IC50 ~ 60 μM) | 3.4-6.3 |
References
Catterall (1992) Cellular and molecular biology of voltage-gated sodium channels. Physiol.Rev. 72 S15. Gordon (1997) Sodium channels as targets for neurotoxins. Mode of action and interaction of neurotoxins with receptor sites on sodium channels. Toxins and Signal Transduction. Eds. Gutman and Lazarovici, pp119-153, Harwood Academic Publishers.