Pharmacology
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7-TM Receptors
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Cellular Processes
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ECM & Adhesion Molecules
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Product Type
All Products
New Products
Small Molecules
Peptides
Controlled Substances
Toxins
Caged Compounds
Fluorescent Probes
Screening Libraries
Ligand Sets
Other Product Types
Research Area
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
Properties of ATPases
| Type | P | F | V |
|---|
| Substances Transported | H+, Na+, K+, Ca2+ | H+ only | H+ only |
| Structural and Functional Features | Large catalytic α-subunits become phosphorylated during solute transport. β-subunits regulate transport | Multiple TM and cytosolic subunits synthesize ATP on β-subunits, powered by movement of H+ down an electrochemical gradient | Multiple TM and cytosolic subunits use energy released from ATP hydrolysis to pump H+ from cytosol to organelle lumen |
| Localization |
H+ pump: plasma membrane of plants, fungi, bacteria Na+/K+ pump: plasma membrane of higher eukaryotes H+/K+ pump: plasma membrane of gastric chief cells Ca2+ pump: plasma membrane of eukaryotic cells Ca2+ pump: sarcoplasmic reticulum membrane in muscle cells |
Bacterial plasma membranes Inner mitochondrial membrane Thylakoid membrane of chloroplast |
Vacuolar membranes in plants, yeast and other fungi Endosomal and lyosomal membranes in eukaryotic cells Plasma membrane of acid-secreting cells (e.g. osteoclasts) |
References
Lodish et al (2000) Molecular Cell Biology. pp590. W.H.Freeman and Company.