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Spring Specials Tocris is pleased to offer 25% off the list price for the following products until the 30th of June 2008:
Potent and selective NOP antagonist
2598 l J 113397 IC50 values are 2.3, 1400, 2200 and > 10000 nM for NOP, κ, μ and δ-opioid receptors respectively). Inhibits nociceptin/orphanin FQ-induced hyperalgesia in the mouse tail-flick test.
Blocker of retinoic acid metabolism
2705 l Liarozole Inhibits several cytochrome P450 enzymes including aromatase (CYP19) and retinoic acid 4-hydroxylase (CYP26). Displays antitumoural activity against androgen-dependent and independent rat prostate carcinomas.
Potent CCR1 chemokine receptor antagonist
2595 l J 113863 Improves paw inflammation, joint damage and dramatically reduces cell infiltration into joints in collagen-induced arthritis in mice.
Selective GnRH receptor antagonist
2730 l AG 045572 Ki values are 2.2, 3.8 and 6.0 nM for mouse, rat and human receptors respectively. Suppresses testosterone and luteinising hormone (LH) levels in vivo.
Competitive NMDA receptor antagonist
1521 l LY 233053 Inhibits NMDA-induced neuronal degeneration and protects from NMDA-induced convulsions in neonatal rats. *For terms and conditions, click here. |
Tocris Bioscience Launches New Unique & Affordable Screening Library (more). Upcoming ConferencesENDO Annual Meeting |
