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Category:
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Nuclear Receptors PPAR Receptors
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Cat.No.
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Product Name
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2150 |
nTZDpa
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Price and Availability
Click here for full price details of
nTZDpa
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Chemical Name:
5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-i
ndole-2-carboxylic acid |
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Biological Activity:
Potent, selective non-thiazolidinedione PPARγ partial
agonist (EC50 = 57 nM); produces ~25% maximum efficacy. Antagonises
full agonist activity by ~60% (IC50 ~ 285 nM). Displays no activity
at PPARα
or PPARδ
receptors. Produces altered receptor conformation, and regulates adipocyte
development and gene expression, in a differential manner to full PPARγ agonists.
Modulates metabolism and insulin sensitivity without causing cardiac
hypertrophy in mice in vivo.
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Technical Data:
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Resources:
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Certificate of Analysis / MSDS:
Certificate of Analysis is currently unavailable on-line. Please contact Customer Service
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References:
Berger et al (2003)
Distinct properties and advantages of a novel peroxisome proliferator-activated
protein γ selective
modulator. Mol.Endocrinol. 17 662.
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View related products by Pharmacological Action
or by Research Area
Keywords: NTZDpa, PPAR Receptors, Potent, Selective PPARg Partial Agonist, Tocris Bioscience
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